Morand-Joubert L, Roudot-Thoraval F, Petit JC, Lerable J, Thauvin M, Mariotti M, Lefrere JJ; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 6th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 6th 1999 Chic Ill. 1999 Jan 31-Feb 4; 6th: 104 (abstract no. 194).
Hospital Saint-Antoine, Paris, France.
GBV-C/HGV being blood-borne and sexually transmitted, the prevalence of the infection is high in HIV-infected patients. However, the long-term consequences of the GBV-C/HGV-HIV co-infection are unknown. For this reason, we undertook a longitudinal study in order to determine the impact of GBV-C/HGV infection on the natural course of HIV infection. This study was based on the follow-up of a cohort of 95 HIV+ individuals with a well-defined duration of HIV infection and screened on the basis of GBV-C/HGV status. GBV-C/HGV viremia was observed in 23 patients, who were shown to carry the virus over a mean period of 7.7 years. The cumulative progression rates from baseline in GBV-C/HGV positive patients and GBV-C/HGV negative patients were as follows: one log increase of HIV load (54.4%, 72.8% respectively, p=0.2); 50% decrease of CD4+ count (43.5%, 83.8%, p=0.05); CDC stage B/C at the end of the follow-up (37.8%, 80.3%, p=0.005). After matching of the GBV-C/HGV positive patients to GBV-C/HGV unexposed patients (negative for viral RNA and for anti-E2 antibody) on age, sex, baseline HIV RNA load and baseline CD4+ count, HIV disease progression appeared clearly worse in GBV-C/HGV RNA negative patients. Our study indicates that the carrying of GBV-C/HGV RNA was associated with a slower immunological, virological and clinical progression of HIV disease in coinfected patients.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Case-Control Studies
- Disease Progression
- GB virus C
- HIV Infections
- HIV Seropositivity
- Health Personnel
- Humans
- Longitudinal Studies
- Prevalence
- RNA
- RNA, Viral
- virology
Other ID:
UI: 102188836
From Meeting Abstracts