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Tools for Insertional Mutagenesis in the Mouse
Release Date: January 25, 2001
Announcement Number: RFA-DA-01-011
Application Receipt Date:
April 11, 2001   
Letter of Intent Date: March 11, 2001

Funding Contact: NINDS Funding
Program Area: Neurogenetics

Brief Description:
This RFA solicits proposals for development of tools and techniques for the establishment of random and targeted sequence-tagged insertion libraries of embryonic stem (ES) cells that can be used to generate mutant mice in which the expression of the tagged gene could be controlled temporally and spatially. The development of such a resource for wide distribution to the scientific community would make it possible to scan the sequence database for any gene of interest and order the corresponding targeted ES cell line. Ideally, the insertional mutagenesis system developed would permit a wide range of genetic analyses and manipulations, including enhancer-trapping, conditional knockouts, conditional expression or overexpression, etc. It also would permit the larger community of investigators to utilize genomic resources efficiently.

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