Funding Resources
Funding Overview
Funding Strategy
Funding Opportunities |
Research
Anticonvulsant Screening
Program
Clinical Research
Counterterrorism
Epilepsy Research Web
Neural Interfaces Program
NIH Roadmap Research
Parkinson's Web
Resources for Scientists
Stem Cell Research
Translational Research
Traumatic Brain Injury
(TBI) Research
Technology Transfer
Office
NINDS is part of the
National Institutes of
Health
Application processes at NIH are changing. Applicant organizations are encouraged to start preparing for this transition by registering with Grants.gov and NIH eRA Commons now. |
Characterization, Behavior and Plasticity of Pluripotent Stem Cells (R01)
Release Date: December 18, 2006
Announcement Number: PA-07-201
Application Receipt Date:
February 5, 2007
June 5, 2007
Funding Contact: David Owens, Ph.D.
Program Area: Repair and Plasticity
Brief Description:
Inviting applications for studies on the characterization, behavior and plasticity of human and non-human stem cells, regulation
of their replication, differentiation, integration and function in the nervous system, and the identification and characterization
of normal and tumor stem cells. An understanding of intrinsic and extrinsic signals, especially those involved in the stem
cell niche, age-dependent processes and genetic factors that govern the activities of pluripotent cells is crucial in order
to utilize them to develop safe and effective treatments for the restoration of function, or to prevent their transformation
into tumor-generating cells. Although animal studies demonstrate that stem or progenitor cells can be derived from a variety
of tissues and from hosts of different ages, the requirements and potential for differentiation of each type of pluripotent
cell appear to be unique. We lack a clear understanding of the intrinsic properties that distinguish one population from another,
and how these populations differ in their response to similar conditions in vitro and in vivo. This Program Announcement,
which replaces PA-01-078 (Biology of Non-Human Stem Cells in the Environment of the Nervous System) and PA-02-025 (Plasticity
of Human Stem Cells in the Nervous System), encourages applications to study the fundamental properties of all classes of
human and non-human stem cells, and to confirm, extend, and compare the behavior of stem cells that are derived from different
sources and ages or exposed to different regimes in vitro and in vivo or derived from tumors. Of high priority are studies
to develop methods for identifying, isolating and characterizing specific precursor populations at intermediate stages of
differentiation into neurons and glia, and their relationship to tumor-generating cells. Projects that address comparisons
between different classes of human stem cells and between human and non-human stem cells would also be directly relevant to
this PA.
Choose an option to view additional funding announcements |
New Announcements | Research Area | RFAs Only | PAs Only | RFPs Only | Notices Only | Supplements Only | All Announcements | Archives |