Notice Number: NOT-DA-08-015

Key Dates
Release Date:  April 23, 2008

Issued by
National Institute on Drug Abuse (NIDA), (http://www.nida.nih.gov)

In November 2005, NIH announced the acquisition of 250 knockout mice from Deltagen and Lexicon and made them available to researchers through publicly funded mouse repositories.  http://grants.nih.gov/grants/guide/notice-files/NOT-OD-06-012.html.  Under the license agreements with Deltagen and Lexicon, researchers who receive the knockout mice lines through NIH are free to publish any results from research involving the lines and also to seek patent or other intellectual property protection for any of the inventions or discoveries resulting from such research.  For more information on the knockout mice and data obtained, go to list of available knockout mice.

NIH is now pleased to announce that Lexicon will make over 2500 knockout mouse strains available (and the list will be updated on a regular basis as new knockouts strains are added http://www.lexpharma.com/pdf/NIH_Lexicon.xls) for purchase by NIH funded investigators under the same terms as the contract NIH used to acquire knockout mice by using NIH grant money. 

Under these terms, a NIH investigator acquiring a Lexicon knockout mouse using his or her grant funds is expected to place the mouse lines in a NIH-supported mouse repository (see instructions below for submitting to MMRRC). Universities, medical schools, and research laboratories will have access to mice and germplasm all over the world.  Lexicon will send heterozygous mice and materials to the investigator. The investigator and institution will be responsible for coordinating with a NIH supported repository to ensure that banks of cryopreserved embryos, sperm, and embryonic stem cells are archived using state-of-the-art procedures. Mice and cryopreserved germplasm will be available from the central repository for a nominal fee to cover the costs of quality control, archiving, shipping, and restocking the archive.    

Investigators acquiring mice are also responsible for ensuring that phenotypic data received from Lexicon is deposited in the Mouse Genome Informatics database or another publicly accessible database. All information provided by Lexicon for each mutant mouse will be made available to researchers worldwide without restriction.
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In summary, NIH funded investigators may use grant money to purchase Lexicon mice if it is within the scope of their grants.  Those interested in requesting administrative supplements to acquire Lexicon knockout mice should contact their Program Director prior to making a request.  When possible, NIH supported investigators are encouraged to pool resources to share the cost of acquiring a mouse with particular null mutation.  Once an investigator has decided to place an order, he or she should email the completed MTA (http://www.nih.gov/science/models/mouse/knockout/NIHInstitutionMTA(FINAL).pdf to the following address: komice@lexpharma.com and we ask that NIH be notified by cc to hardee@mail.nih.gov.

Paper submissions of request and the MTA should be addressed to:

Shiv J. Patel
Manager, Alliance Management
Lexicon Pharmaceuticals
8800 Technology Forest Place
The Woodlands, Texas 77381
Phone: (281) 863-3293
EMAIL: komice@lexpharma.com

Instructions for Submitting Lexicon Knockout Mice to the Mutant Mouse Regional Resource Centers:

1. Read the terms and conditions for submitting your application using the following link:
http://www.mmrrc.org/submission/strain_submission_terms.html.
 
2. Indicate that you have read, accept and can meet the terms and conditions by clicking the “I accept” button.

3. Provide information about the mouse you are submitting. Please note that Lexicon mice are pre-authorized for MMRRC acquisition. Complete item 1 by clicking the “YES” button and selecting “Lexicon Strain” in the pull down box.

4. After submitting information on the characteristics of your mouse, please complete  your application by clicking on the “Submit Application to “MMRRC” button.

5. Questions and assistance is available by contacting Customer Service at 1-800-910-2291. The MMRRC Strain Acquisition Coordinator can be contacted via telephone: 1-207-288-6373.

Inquiries

Colin Fletcher, Ph.D.
Program Director
Knock Out Mouse Program (KOMP)
National Human Genome Research Institute
National Institutes of Health
5635 Fishers Lane, Suite 4076, MSC 9305
Bethesda, Maryland, 20892-9305
Phone: (301) 496-7531
FAX:   (301) 480-2770
E-Mail: fletcherc2@mail.nih.gov or colin_fletcher@nih.gov

FedEx/USP/Other Courier Delivery Address:
NIH/NHGRI/DER
5635 Fishers Lane, Suite 4076 MSC 9305
Rockville, Maryland 20852

http://www.knockoutmouse.org
http://www.genome.gov/KOMP
http://www.nih.gov/science/models/mouse/knockout/

or

Jonathan D. Pollock, Ph.D.
Chief
Genetics and Molecular Neurobiology Research Branch
Division of Basic Neuroscience and Behavioral Research
National Institute on Drug Abuse
6001 Executive Blvd.
Bethesda, MD 20892
Phone: 301-435-1309
FAX: 301-594-6043
E-mail. jpollock@mail.nih.gov

or

Thomas M, Hardee
Contracting Officer
Office of Acquisition
National Institute of Environmental Health Sciences
P.O. Box 12874   
79 T.W. Alexander Drive,
Bldg. 4401 Research Commons
Research Triangle Park, NC 27709
Phone: (919) 541-0429 
FAX: (919) 541-2712 
Cell: (919) 602-2233
hardee@mail.nih.gov

Weekly TOC for this Announcement
NIH Funding Opportunities and Notices

	Office of Extramural Research (OER)			National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892			Department of Health and Human Services (HHS)
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