The Thrombolysis in Myocardial Infarction 2 (TIMI II)
Trial
Objectives:
To compare the following two treatment strategies in
patients with acute myocardial infarcton: (1) routine coronary arteriography
performed 18 to 48 hours after the admnistration of rt-PA, followed by
prophylactic PTCA (or CABG) if arteriography demonstrated that the anatomy was
suitable (this was termed 'invasive strategy') and (2) conventional care
without coronary arteriography and PTCA during the six weeks after random
assignment to treatment, unlessthere was evidence of recurrent spontaneous or
exercise-induced ischemia (the 'conservative strategy'). One substudy included
in this trial examined the effects of early as compared with deferred
administration of a relatively cardioselective beta-andrenergic blocking agent
in eligible patients. Pateients were treated with recombinant tissue
plasminogen activator (rt-PA). Data are from analysis files as of January 1991.
The patient population was 3,339.
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Study Website |
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Study Documentation |
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Data Distribution Agreement |
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