Honolulu Heart Program (HHP)
Objectives:
The initial objectives of the Honolulu Heart Program
were to: 1) estimate morbidity and mortality from coronary heart disease and
stroke among Japanese men in Honolulu; 2) compare morbidity and mortality from
coronary heart disease and stroke among Japanese men in Japan, Honolulu, and
San Francisco; 3) investigate relationships among risk factors, coronary heart
disease, and stroke in Japanese men in Honolulu; 4) compare distributions of
risk factors among men in Japan, Honolulu, and San Francisco, and relate
similarities and differences in risk factors to the occurrence of disease in
these areas and in other populations, including Framingham and Puerto Rico; 5)
conduct an autopsy study, and to relate pathological findings to morbidity and
mortality data; and 6) investigate relationships between risk factors and
pathological evidence of atherosclerosis and its complications.
Background:
The Honolulu Heart Program was initiated in 1965 by
the NHLBI as a prospective study of environmental and biological causes of
cardiovascular disease among Japanese Americans living in Hawaii. This
population was known to have low incidence of coronary heart disease and higher
incidence of stroke. The study provided opportunities to investigate
relationships among disease frequencies, pathologic findings, and disease
predictors in the cohort and to compare the findings in this population with
those in other populations, especially cohorts of Japanese men resident in
Japan or the U.S.
Subjects:
American men of Japanese ancestry born in 1900-1919
and living on the island of Oahu in 1965; age at entry 28-62 years; sample
size: 8,006.
Design:
The study began in 1965 with the first examination of
a cohort of 8,006 Japanese-American men residing on the island of Oahu, Hawaii
who were born during the period 1900-1919. The first examination was completed
in 1968 and was followed by the initiation of a second examination that same
year. Three subsequent sub-examinations (Lipoprotein Exams I, II and III) were
conducted between 1970 and 1982 to collect lipid measurements on a subset of
those who participated in Exam 2. The fourth examination of surviving members
of the original cohort was conducted during 1991-93 and collected data on 3,741
men. The National Institute on Aging conducted a fifth examination of
approximately 3,400 survivors focusing on dementia and its precursors. This
effort was concluded in 1996. Morbidity and mortality follow-up continues
through grant and contract-supported efforts, and the current HHP dataset
includes events through 1998.
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Study Documentation |
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Coding Manuals |
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Exam 1 - PDF, 290K
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Exam 2 - PDF, 291K
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Exam 3 - PDF, 290K
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Exam 4 - PDF, 1,236K
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Jenkins Physical Activity - PDF, 98K
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Lipoproteins1 - PDF, 144K
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Lipoproteins2 - PDF, 225K
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Lipoproteins3 - PDF, 208K
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Acculturation - PDF, 177K
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Cognitive Function - PDF, 671K
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Surveillance Manual - PDF, 350K
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Mortality Codebook - PDF, 98K
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Morbidity Codebook - PDF, 135K
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Data Distribution Agreement |
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