Asthma Clinical Research Network: Measuring Inhaled Corticosteroid Efficacy (ACRN: MICE)
Objectives:
The purpose of this study was to compare the relative benficial and systemic effects in a dose-response relationship for 2 ICSs.
Background:
A clinical model is needed to compare inhaled corticosteriods (ICS) with respect to efficacy.
Subjects:
30 asthmatic individuals 18 to 55 years of age. this was a feasibility study, not a comparative trial, therefore the sample size calcualtion was based on an appropriate sample size for extimating the common variance with som elevel of precision.
Conclusions:
High-dose ICS therapy did not significantly increase the efficacy of measures that were evaluated but it did increase the systemic effect measure, overnight cortisol secretion.
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