Reggy A, Wong T, Chiasson M, Simonds R, Loo V, Heffess J; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 5th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 5th 1998 Chic Ill. 1998 Feb 1-5; 5th: 224 (abstract no. LB7).
Centers for Disease Control and Prevention, Atlanta, GA.
Background: In NYC, the number of HIV/AIDS deaths dropped 30% between 1995 and 1996. We evaluated the association between combination antiretroviral therapy with protease inhibitors (PI combo) and mortality among AIDS patients. Methods: In this population-based case-control study, 150 cases and 150 controls were randomly selected (male:female, 2:1) from the NYC HIV/AIDS reporting system (HARS). Cases were persons with AIDS diagnosed during 1994-1996, who died of AIDS-related causes in 1996. Controls, matched with cases on year of AIDS diagnosis and gender, were not known to have died by the end of 1996. Data were obtained for 1995-1996 from HARS, death certificates, and medical charts. Results: Data are complete on 99 cases and 102 controls. Cases and controls were similar in age (mean, 40 years for both), sex (about two-thirds male), proportion black or Hispanic (84% for both), proportion injecting drug users (about half), and proportion receiving publicly funded medical care (about 80%). The median CD4 count at AIDS diagnosis was 29 cells/microliter for cases and 109 cells/microliter for controls (p less than 0.001). In 1996, 10% of cases and 32% of controls were on PI combo (p less than .001). After stratifying by CD4 count, controls were still more likely to receive PI combo (Mantel-Haenszel OR=5.7, p less than .001). Conclusions: The preliminary results of this population-based study suggest a strong association between death following AIDS diagnosis and not using PI combo. This association supports the likelihood that the decline in NYC AIDS deaths in 1996 resulted from increased use of PI combo.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Case-Control Studies
- Death Certificates
- Disease Progression
- Female
- HIV Infections
- HIV Seropositivity
- Humans
- Male
- New York City
Other ID:
UI: 102236350
From Meeting Abstracts