Robertson JR, Skidmore CA, Roberts JJ, Elton RA; International Conference on AIDS.
Int Conf AIDS. 1990 Jun 20-23; 6: 287 (abstract no. Th.C.649).
Edinburgh Drug Addiction Study, Edinburgh, Scotland
OBJECTIVE: Survival analysis of drug users infected with HIV was carried out and relationship of progression with cofactors such as age, sex and continued drug use assessed. METHODS: In a cohort of 352 known intravenous drug users 143 were found to be positive. These individuals were followed where possible and serial testing for indicators of immunosuppression were carried out (CD4 counts, Beta 2 microglobulin, antigen and antibody core index) over a 3 year period. Three estimates of seroconversion dates were used. Firstly, using last negative sample (or 1st June 1983 if later or missing as this was the time when HIV was thought to enter the cohort), n=119. Secondly, using the first positive sample, n=112. Thirdly, using the mid point of these (where seroconversion date was known to less than 1 year), n=58. Using a Cox Regression, survival to AIDS was analysed and cofactors tested. RESULTS: Sex was not significantly associated with progression but age at seroconversion was significant in group 1 and 2, p less than 0.1 and 3 p less than 0.05. In group 3 (the most accurate date of seroconversion) 12% of those less than 20 years had AIDS, 18% of those between 20 and 25, and 32% over 25 years. Continued drug use was not significantly associated with progression in any of the groups. CONCLUSIONS: Progression was found to be associated with age at seroconversion, the older individuals becoming ill earlier. Drug use was not found to be associated with progression or, putting it another way, abstinence was not found in this group to prevent progression.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- CD4 Lymphocyte Count
- Disease Progression
- HIV
- HIV Infections
- HIV Seropositivity
- Substance Abuse, Intravenous
- Survival Analysis
- mortality
Other ID:
UI: 102182246
From Meeting Abstracts