Biography
Dr. Landgren received his undergraduate degree in 1993 from Lund University Medical School (Lund, Sweden) and his M.D. in 1995 from the Karolinska Institute (Stockholm, Sweden). Following clinical training as a hematology/internal medicine specialist physician and receipt of a Ph.D. in clinical epidemiology (2002) at Karolinska Institute in Sweden, he worked as an attending physician and conducted research on etiology, diagnostics, and prognostics in lymphoproliferative tumors at Hematology Center at Karolinska University Hospital and Institute in Stockholm, Sweden. In 2004, he came to the National Cancer Institute as a visiting fellow. Since 2006, he has been an Investigator in the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics.
Dr. Landgren’s major research interests are in the causation, natural history, diagnostics, prognostics, and survival of hematopoietic malignancies and related precursor conditions, including monoclonal gammopathy of undetermined significance (MGUS) and monoclonal B-cell lymphocytosis (MBL). His research focuses on host-, disease-, treatment-, and immune-related factors in the pathway from precursor to full-blown malignancy, and their relation to outcome.
Research Interests
- Identification of genetic risk factors for hematopoietic malignancies and related precursors
- Definition of the roles for infectious antigens, inflammation, chronic immune stimulation, and immune modulation in hematopoietic carcinogenesis
- Identification of predictors for progression – from precursor to malignancy, and outcome
- Assessment and definition of host- and disease-related diagnostic/prognostic factors
- Examination of novel treatments and trends in outcome patterns for hematopoietic tumors
Keywords
Precursor conditions, risk factors, familial aggregation, racial disparity, etiology, prognosis, survival, lymphoproliferative and myeloproliferative malignancies, monoclonal gammopathy of undetermined significance, monoclonal B-cell lymphocytosis, inflammation, autoimmunity, infections, chronic immune stimulation, immunodeficiency
Selected Publications
- Landgren O, Gridley G, Turesson I, Caporaso NE, Goldin LR, Baris D, Fears TR, Hoover RN, Linet MS. Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African-American and White veterans in the United States. Blood. 2006; 107(3):904-6.
- Landgren O, Goldin LR, McMaster ML, Gridley G, Hemminki K, Linet MS. Int J Cancer. Familial characteristics of autoimmune and hematologic disorders in 8,406 multiple myeloma patients: a population-based case-control study in Sweden. Int J Cancer. 2006;
118(12):3095-3098.
- Landgren O, Engels EA, Pfeiffer RM, Gridley G, Mellemkjaer L, Olsen J, Hemminki K, Wheeler W, Linet MS, Goldin LR.
Autoimmunity and susceptibility to Hodgkin lymphoma:
A population-based case-control study in Scandinavia J Natl Cancer Inst. 2006; 98(18): 1321-30.
- Landgren O, Rapkin J, Caporaso, NE, Mellemkjaer L, Gridley G, Goldin LR, Engels EA.
Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia. Blood. 2007;109(5):2198-201.
- Kristinsson SY, Landgren O, Dickman PW, Derolf ÅR, Björkholm M.
Patterns of survival in multiple myeloma: A population-based study of patients diagnosed in Sweden 1973 to 2003. J Clin Oncol. 2007;25(15):1993-9.
- Giordano TP, Henderson L, Landgren O, Chiao EY, Kramer JR, El-Serag H, Engels EA.
Risk of Non-Hodgkin Lymphoma and Lymphoproliferative Precursor Diseases in U.S. Veterans with Hepatitis C Virus. JAMA. 2007; 297(18): 2010-2017.
- Turesson I, Linet MS, Bjorkholm M, Kristinsson SY, Goldin L, Caporaso NE, Landgren O. Ascertainment and diagnostic accuracy for hematopoietic lymphoproliferative malignancies in Sweden 1964-2003.Int J Cancer 2007;121(10):2260-6.
- Landgren O and Caporaso NE. New aspects in descriptive, etiological, and molecular epidemiology of Hodgkin lymphoma. Hematol Oncol Clin North Am. 2007;21(5):825-40.
- Landgren O and Kyle RA. Multiple myeloma, chronic lymphocytic leukaemia, and associated precursor diseases. J Haematol. 2007;139(5):717-2
- Landgren O, Katzmann JA, Hsing AW, Pfeiffer RM, Kyle RA, Yeboah ED, Biritwum RB, Tettey Y, Adjei AA, Larson DR, Dispenzieri A, Melton J, Goldin LR. McMaster ML, Caporaso NE, Rajkumar SV. Prevalence of monoclonal gammopathy of undetermined significance among men in Ghana. Mayo Clin Proc. 2007;82(12):1468-73.
