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Environmental And Genetics in Lung cancer Etiology

Descriptive Statistics

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Population in the catchment area and EAGLE subjects
by area of residence, gender, and age (matching variables)
Area Population Cases Controls
No. % No. % No. %
Brescia 272,786 16.6 275 13.1 248 11.7
Milan 963,341 58.7 1369 65.2 1440 67.9
Monza 155,491 9.5 144 6.8 117 5.5
Pavia 122,036 7.4 137 6.5 130 6.1
Varese 128,420 7.8 176 8.4 185 8.7
Total 1,642,074 100.0 2101 100.0 2120 100.0
 
Gender No. % No. % No. %
Females 867,310 52.8 449 21.4 500 23.6
Males 774,764 47.2 1652 78.6 1620 76.4
Total 1,642,074 100.0 2101 100.0 2120 100.0
 
Age No. % No. % No. %
35-39 242,876 14.8 12 0.6 17 0.8
40-44 203,923 12.4 19 0.9 28 1.3
45-49 185,568 11.3 52 2.5 71 3.3
50-54 206,127 12.6 133 6.3 127 6.0
55-59 183,214 11.2 240 11.4 300 14.1
60-64 196,734 12.0 359 17.1 371 17.5
65-69 167,764 10.2 474 22.6 489 23.1
70-74 143,191 8.7 471 22.4 424 20.0
75-79 112,677 6.9 341 16.2 293 13.8
Total 1,642,074 100.0 2101 100.0 2120 100.0

 

EAGLE lung cancer cases by histology and cigarette smoking status
Histology Never
smokers		 Former
smokers		 Current
smokers		 Missing Total
Females No. % No. % No. % No. % No. %
Non small cell carcinoma (NSCLC) 101 87.8 96 78.0 147 73.1 9 90.0 353 78.6
Adenocarcinoma 85 73.9 64 52.0 91 45.3 4 40.0 244 54.3
Squamous cell 7 6.1 19 15.4 22 11.0 1 10.0 49 10.9
Large cell 2 1.7 6 4.9 12 6.0 0 0.0 20 4.5
NSCLC, not defined 7 6.1 7 5.7 22 11.0 4 40.0 40 8.9
Small cell carcinoma 3 2.6 8 6.5 29 14.4 0 0.0 40 8.9
Others (mixed types) 5 4.4 13 10.6 18 9.0 1 10.0 37 8.2
Missing 6 5.2 6 4.9 7 3.5 0 0.0 19 4.2
Total 115 100.0 123 100.0 201 100.0 10 100.0 449 100.0
 
Males No. % No. % No. % No. % No. %
Non small cell carcinoma (NSCLC) 28 84.9 607 80.1 663 78.8 13 65.0 1311 79.4
Adenocarcinoma 20 60.6 283 37.3 305 36.3 6 30.0 614 37.2
Squamous cell 5 15.2 233 30.7 241 28.7 5 25.0 484 29.3
Large cell 0 0.0 23 3.0 34 4.0 0 0.0 57 3.5
NSCLC, not defined 3 9.1 68 9.0 83 9.9 2 10.0 156 9.4
Small cell carcinoma 1 3.0 73 9.6 100 11.9 2 10.0 176 10.7
Others (mixed types) 1 3.0 39 5.2 39 4.6 1 5.0 80 4.8
Missing 3 9.1 39 5.2 39 4.6 4 20.0 85 5.1
Total 33 100.0 758 100.0 841 100.0 20 100.0 1652 100.0

 

EAGLE lung cancer cases by stage and cigarette smoking status
Stage Never
smokers		 Former
smokers		 Current
smokers		 Missing Total
Females No. % No. % No. % No. % No. %
0 0 0.0 0 0.0 0 0.0 0 0.0 0 0.0
IA 11 9.6 13 10.6 20 10.0 2 20.0 46 10.2
IB 14 12.2 13 10.6 23 11.4 0 0.0 50 11.1
IIA 0 0.0 3 2.4 4 2.0 0 0.0 7 1.6
IIB 10 8.7 10 8.1 14 7.0 0 0.0 34 7.6
IIIA 13 11.3 18 14.6 26 12.9 0 0.0 57 12.7
IIIB 18 15.6 15 12.2 28 13.9 3 30.0 64 14.3
IV 48 41.7 50 40.7 81 40.3 5 50.0 184 41.0
X 1 0.9 1 0.8 5 2.5 0 0.0 7 1.6
Total 115 100.0 123 100.0 201 100.0 10 100.0 449 100.0
 
Males No. % No. % No. % No. % No. %
0 0 0.0 1 0.1 0 0.0 0 0.0 1 0.1
IA 3 9.1 78 10.3 59 7.0 1 5.0 141 8.5
IB 1 3.0 109 14.4 94 11.2 1 5.0 205 12.4
IIA 0 0.0 11 1.4 11 1.3 0 0.0 22 1.3
IIB 4 12.1 65 8.6 76 9.0 1 5.0 146 8.8
IIIA 1 3.0 78 10.3 97 11.5 1 5.0 177 10.7
IIIB 4 12.1 102 13.5 150 17.8 3 15.0 259 15.7
IV 20 60.6 295 38.9 333 39.6 12 60.0 660 40.0
X 0 0.0 19 2.5 21 2.5 1 5.0 41 2.5
Total 33 100.0 758 100.0 841 100.0 20 100.0 1652 100.0

 

EAGLE subjects by cigarette smoking status
Females Cases Controls
No. % No. %
Never smokers 115 25.6 282 56.4
Former smokers 123 27.4 110 22.0
Current smokers 201 44.8 107 21.4
Missing 10 2.2 1 0.2
Total 449 100.0 500 100.0
 
Males No. % No. %
Never smokers 33 2.0 397 24.5
Former smokers 758 45.9 799 49.3
Current smokers 841 50.9 420 25.9
Missing 20 1.2 4 0.3
Total 1652 100.0 1620 100.0

 

EAGLE subjects by cigarette pack-years
(former/current smokers)
Pack-years Cases Controls
Females No. % No. %
<10 32 10.5 97 44.7
10-19 56 18.4 50 23.0
20-29 65 21.4 32 14.8
30-39 59 19.4 17 7.8
40-49 40 13.2 11 5.1
50-59 22 7.2 5 2.3
60+ 30 9.9 5 2.3
Total 304 100.0 217 100.0
 
Males No. % No. %
<10 37 2.5 264 21.7
10-19 81 5.4 199 16.4
20-29 155 10.3 226 18.6
30-39 265 17.6 187 15.4
40-49 296 19.7 154 12.7
50-59 233 15.5 83 6.8
60+ 439 29.2 104 8.6
Total 1506 100.0 1217 100.0

 
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