BROWN SD, TRACZEWSKI MM, BARRY AL; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. F-1338.
The Clinical Microbiology Institute, Wilsonville, OR
BACKGROUND: PNU-288034 is a new oxazolidinone antimicrobial agent with activity against a wide variety of Gram-positive microorganisms. METHODS: An eight-laboratory study was conducted to generate data to determine quality control (QC) limits for three standard QC organisms when testing susceptibility to PNU-288034 by microbroth dilution. Three different lots of Mueller-Hinton broth were used. The broth was supplemented with lysed horse blood for testing S. pneumoniae. All susceptibility tests were performed by methods outlined by the NCCLS. Each laboratory performed 30 MIC determinations for each QC strain. RESULTS: Colony counts ranged from 6 X 10[4] to 6.4 X 10[6]. Significant lot-to-lot variation was not observed. All tests were very reproducible and the following quality control limits are proposed: CONCLUSIONS: Microbroth dilution quality control ranges are proposed for the oxazolidinone PNU-288034.
Publication Types:
Keywords:
- Laboratories
- Microbial Sensitivity Tests
- Oxazolidinones
- Phenylurea Compounds
- Quality Control
- pyriminil
Other ID:
UI: 102267762
From Meeting Abstracts