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Investigators at the National Institute of Neurological Disorders and Stroke (NINDS) are seeking children with porencephaly, stroke, and cerebral palsy for a study of abnormal acquired and genetic coagulation factors. In the study, researchers will measure a series of potential risk factors for stroke that include autoimmune, inflammatory, and genetic clotting factor abnormalities. By identifying the factors that contribute to childhood stroke, porencephaly, and cerebral palsy, researchers hope this study will lay the groundwork for future research projects that will explore potential treatments.

Eligible patients must be less than 15 years of age with a history of porencephaly, cerebral infarction (stroke), and/or cerebral palsy and have a diagnosis of porencephaly or stroke confirmed by computed tomography (CT), magnetic resonance imaging (MRI), and/or Doppler ultrasonography.

The study consists of a 30-minute telephone interview/questionnaire and a blood sample, and will be conducted at the National Institutes of Health (NIH) Clinical Center in Bethesda, MD. All study-related expenses will be paid by the NIH. The study will be carried out under testing and safety standards of the U.S. Department of Health and Human Services.

For more information, physicians should send a referral letter and a copy of the patient's recent medical records to Dr. Karin Nelson or Dr. John Lynch, NINDS, NIH, 10 Center Drive, Building 10, Room 5S220, Bethesda, MD 20892-1447; telephone: (301) 496-1714; fax: (301) 496-2358; email: lynchj@ninds.nih.gov.

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This content has been adapted from the original NINDS Notes publication. For the most up-to-date funding information, please visit the Funding Opportunities section of the NINDS web site.  For the most recent information on NINDS studies, please visit the NINDS Patient Recruitment web site.