Rubin HC, Patterson TL, Atkinson JH, Kaplan RM, Koch WL, McCutchan JA, Chandler JL, Grant I; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 194 (abstract no. PB0205).
UCSD.
OBJECTIVES: To explore the impact of depressive symptoms on health-related quality of life in people with HIV. METHODS: HIV+ (n = 285) and HIV- (n = 84) men participating in a longitudinal cohort study were administered the Hamilton Depression Index (HAM-D) and the Quality of Well Being Scale (QWB)--a general health-related outcome measure--at baseline (T1) and six months later (T2). Clinically meaningful depression was defined as HAM-D > or = 10; t-tests and ANOVA were used to examine QWB scores in subgroups where in depression developed or resolved on follow-up. RESULTS: At T1, there is a decline in QWB scores among HIV+ subjects with increasing Hamilton scores (F = 21.60, p < 0.001). Among those HIV+ subjects who developed depressive symptoms from T1 to T2 (n = 22), there was a decline in their QWB scores (t = 2.62, p = 0.016). HIV subjects who had depressive symptoms at T1 which resolved at T2 (n = 32), showed a rise in QWB scores (t = -2.00, p = 0.054). There were no significant differences in QWB scores in the group that remained depressed or in the group which remained symptom free between T1 and T2. CONCLUSIONS: The QWB appears to be a valid measure of changes in quality of life associated with depressive symptoms in HIV. Because of the morbidity associated with depressive symptoms, identification and treatment of mood symptoms and syndromes is an important priority.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Cohort Studies
- Depression
- Depressive Disorder
- HIV Infections
- HIV Seropositivity
- Humans
- Life
- Longitudinal Studies
- Male
- Quality of Life
- Quality-Adjusted Life Years
Other ID:
UI: 102208480
From Meeting Abstracts