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Title: Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review.
Author: Varela-Lema L,Taioli E,Ruano-Ravina A,Barros-Dios JM,Anantharaman D,Benhamou S,Boccia S,Bhisey RA,Cadoni G,Capoluongo E,Chen CJ,Foulkes W,Goloni-Bertollo EM,Hatagima A,Hayes RB,Katoh T,Koifman S,Lazarus P,Manni JJ,Mahimkar M,Morita S,Park J,Park KK,Pavarino Bertelli EC,de Souza Fonseca Ribeiro EM,Roy B,Spitz MR,Strange RC,Wei Q,Ragin CC
Journal: Genetics in medicine : official journal of the American College of Medical Genetics 10(6):369-84
Year: 2008
Month: June

Abstract: The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.