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Award Abstract #0235293
Organic Free Radical Chemistry
| NSF Org: |
CHE
Division of Chemistry
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| Initial Amendment Date: |
January 31, 2003 |
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| Latest Amendment Date: |
November 17, 2004 |
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| Award Number: |
0235293 |
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| Award Instrument: |
Continuing grant |
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| Program Manager: |
Tyrone D. Mitchell
CHE Division of Chemistry
MPS Directorate for Mathematical & Physical Sciences
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| Start Date: |
February 1, 2003 |
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| Expires: |
January 31, 2006 (Estimated) |
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| Awarded Amount to Date: |
$435000 |
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| Investigator(s): |
Martin Newcomb men@uic.edu (Principal Investigator)
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| Sponsor: |
University of Illinois at Chicago
809 S MARSHFIELD RM 608
CHICAGO, IL 60612 312/996-9406
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| NSF Program(s): |
UNIMOLECULAR PROCESSES
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| Field Application(s): |
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| Program Reference Code(s): |
OTHR,9146,0000
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| Program Element Code(s): |
1942
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ABSTRACT
The focus of this research is to develop a systematic study of radical heterolysis reactions. The research will include kinetic and mechanistic studies of radical cations, focusing on radical cations believed to be involved in the rearrangement of methylmalonyl/coenzyme-A to succinate in vivo. Strained 3-membered ring "reporter groups" will be synthesized and opened photolytically to measure the rate of radical formation by UV spectroscopy. This approach is well suited for the study of alpha- and beta-carboxylate functionalized radicals believed to be involved in the chemistry of B12 dependent enzymes.
With this Renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Martin E. Newcomb of the Department of Chemistry at the University of Illinois, Chicago. Professor Newcomb will focus his research on the use of lasers to break critical bonds related to the function of vitamin B12 in the human body. This work will have impact on the design of new methods for catalysis in the pharmaceutical industry, as well as important impacts on the understanding of enzyme function. The educational activity of the award revolves around the training of graduate students in the study of short-lived chemical intermediates.
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