.

Prcposal for Study of

the Effects of Sickling and the Carrier

State of G&D deficiency in the Population

of the Collaborative Study

'Principal Investigators:

Dr. N,.C. Myrianthopoulos, PRB, NINDS .. : : . .

. . .

Dr. L. Froehlich, PRD, MINDS

.   .   Dr. Robert Murray, Howard University

Objectives

,

To study the effects of sickling and of the carrier state of

G&D deficiency on the course and outcome of pregnancy; and the growth

and development of children with sickle-cell trait, and C6PD deficiency.

Background

1. . Sickle cell anemia and glucose 6 phosphate dehydrogenase (G6PD)
                                                                          . _

deficiency anemia are two genetically determined hpolytic an&as
found in very high frequency among the Negro population of the United

states.
        ._.

Ihe gene for S hemoglobin is inherited as an inccxuplete dominant

so that the heterozygotes show sickle-cell trait while the homozygotes

have frank anemia.~ It is estimated that approximately I-0$ of Negroes

in the United States are sicklers while about 3 per lOOO.have anemia.

The hazards of sickle-cell anemia are well known:  recurrent episodes '