Liesnard C, Przedborski S, Farber CM; International Conference on AIDS.
Int Conf AIDS. 1989 Jun 4-9; 5: 281 (abstract no. M.B.P.357).
Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
METHODS: During a follow-up period of 0.5 to 39 months (mean: 13.9 months) sera of 30 European and 16 African HIV infected patients (pts) at all stages of the disease (i.e.: asymptomatic, PGL, ARC, AIDS) were retrospectively investigated for the presence of HIV antigen (Ag), core antibodies (Ab) and envelope (env) Ab (Abbott Diagnostics-North Chicago-I1). RESULTS: In all pts, env Ab were detected in high titers without significant variations during the follow-up. HIV Ag was detected in the serum samples of 14 pts: 1 African with AIDS and 13 Europeans. At the beginning of the follow-up, 10% of the European pts were antigenemic and 20% at the end. Core Ab were detected during the follow-up period in all the Africans except in the pt with HIV Ag. The geometric mean (GM) of core Ab titers was 1/6738 in the asymptomatic pts and 1/113 in the AIDS pts. All European pts without HIV antigenemia had core Ab; 4 of them lost their Ab during the follow-up period. 9 out of 13 European HIV antigenemic pts had core Ab; 4 of them lost their Ab during the follow-up period. The GM of core Ab titers was 1/26 in the asymptomatic pts and 1/5.5 in the AIDS pts. CONCLUSION: HIV Ag is rarely expressed in African pts; moreover, even in the late stage of the disease, HIV Ag is not detected in 37% of European pts and detection is intermittent. In contrast, the decline or the disappearance of core Ab is clearly related with evolution of the disease, in African like in European pts. Follow-up of quantitative dosage of core Ab seems to be of more value as a prognostic marker than the detection of HIV Ag.
Publication Types:
Keywords:
- AIDS Vaccines
- AIDS-Related Complex
- Acquired Immunodeficiency Syndrome
- Antibodies
- Antibodies, Viral
- Chicago
- HIV
- HIV Antibodies
- HIV Antigens
- HIV Infections
- HIV Seropositivity
- Humans
- Virion
- immunology
- organization & administration
Other ID:
UI: 102177211
From Meeting Abstracts