Deschamps MM, Pape JW, Johnson WD; International Conference on AIDS.
Int Conf AIDS. 1994 Aug 7-12; 10: 144 (abstract no. PB0002).
OBJECTIVE: To determine the Natural history of HIV infection in seropositive heterosexuals with known date of seroconversion. METHODS: From 1987-1993, 19 individuals from 475 discordant couples seroconverted, based on CDC definition. Date of HIV seroconversion is midpoint between last HIV (-) and first HIV (+). They were evaluated clinically every 3 months with CD4 count every 6 months. The following endpoints were: 1. Development of symptomatic conditions (CDC definition category A and B). 2. AIDS. 3. Death. RESULTS: After a median follow-up period of 32 months 4/19 became symptomatic. The symptom-free period was 15 months. Initial manifestations were: generalized lymphadenopathy in 3, Herpes zoster in 1; 2/19 developed AIDS at a mean of 48 months (AIDS Latency period). The time period from seroconversion to death is 76 months with an AIDS survival time of 28 months. Fifteen seroconverters remained free of symptom after a median follow-up time of 30 months: with CD4 count > 500 in 11 individuals, and < 475 in 4 individuals. CONCLUSION: After a median period of 32 months, 4/19 seroconverters became sick, 2/19 developed AIDS and died; the remainders are free of symptoms. This study in on-going and will be updated.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- HIV Infections
- HIV Seropositivity
- Haiti
- Herpes Zoster
- Humans
Other ID:
UI: 102208260
From Meeting Abstracts