Lifson AR, Hessol N, Rutherford G, O'Malley P, Barnhart L, Buchbinder S, Cannon L, Bodecker T, Holmberg S, Harrison J; International Conference on AIDS.

Int Conf AIDS. 1990 Jun 20-23; 6: 142 (abstract no. Th.C.33).

Dept. Public Health, San Francisco CA, USA

OBJECTIVE: To determine the relationship between duration of HIV infection and clinical and immunologic status in a cohort of homosexual and bisexual men. METHODS: From 1978 to 1980, we recruited 6,706 homosexual and bisexual men for studies of hepatitis B; men included in this analysis had well characterized dates of seroconversion (DSC) from 1977-1989. Using Kaplan-Meier analysis, we calculated the cumulative risk of AIDS by duration of HIV infection. We also analyzed additional clinical and laboratory data for men enrolled in our prospective studies by estimated DSC. RESULTS: Based on analysis of 489 men, 1% developed AIDS within 2 years of infection, 8% within 4 years, 20% within 6 years, 37% within 8 years, 51% within 10 years, and 54% within 11 years (95% C.I. = 49-59%). 341 men had an estimated DSC before 1981 and had either developed AIDS or been clinically evaluated within the last 2 years. Of these men, 202 (59%) developed AIDS, 64 (19%) had AIDS-related conditions (ARC), 9 (3%) had asymptomatic generalized lymphadenopathy, and 66 (19%) had no signs or symptoms of HIV infection. Of 73 men without AIDS or ARC whose DSC was before 1981 and on whom T-lymphocyte subsets were available, 6 (8%) had an absolute T4 count less than or equal to 200 cells/mm3, 29 (40%) had 201-500 T4 cells, and 38 (52%) had greater than 500 T4 cells. The proportion of men with clinical or laboratory evidence of immunodeficiency (AIDS, ARC, or less than or equal to 200 T4 cells) increased from 0% of men with an estimated DSC after 1986 to 80% of men with an estimated DSC before 1981. CONCLUSION: The risk of immunodeficiency increases with duration of HIV infection, although some men infected for greater than or equal to 9 years appear immunocompetent.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS-Related Complex
• Acquired Immunodeficiency Syndrome
• Bisexuality
• CD4-Positive T-Lymphocytes
• HIV Infections
• Health Personnel
• Homosexuality
• Humans
• Male
• Natural History
• Prospective Studies
• epidemiology

Other ID:

• 10003390

UI: 102181643

From Meeting Abstracts