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X4/R5 Ratio Is a Sensitive Surrogate Marker of Long Term Immunovirologic Efficacy of HAART in Early HIV Infection.

PARISI SG, BIASIN M, SARMATI L, MAZZI R, CONCIA E, BOASSO A, ANDREONI M, UCCELLA I, CLERICI M; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. I-1943.

Universita di Verona, Verona, Italy

Objective: Quantitative immunovirologic parameters were evaluated in 7 early HAART treated patients (>500 CD4/mL) and in 3 naive untreated patients. METHODS: 7 naive, HAART treated (Htr) early patients and 3 naive not treated (Ntr) patients; baseline HIV plasma viremia was <5000 copies in 5/7 Htr and in Ntr patients. Plasma viremia, proviral DNA, CD4 cell counts and % as well as CXCR4 and CCR5-specific mRNA were evaluated at baseline and during therapy. Results from the baseline and 40 months of therapy are reported. RESULTS: Plasma viremia at month 40 was undetectable (<20 copies/ml) in 6/7 Htr. In these patients proviral DNA was greatly reduced (from 579 to 45 copies per 106 CD4), CD4 % increased significantly (from 32 to 39%), and a conspicuous reduction in the X4/R5 ratio was seen (from 894 to 325). Conversely, in the only patient failing HAART (lack of compliance) CD4 percentage were unmodified (from 31 to 33%) and an increase in proviral DNA (nadir from 40 to 122) and in the X4/R5 ratio (from 479 to 1821) was detected. Over 34 months Ntr patients remained stable in CD4 cells (from 31 to 30%), HIV-1 viral load and X4/R5 ratio markedly increased (from 1510 to 14460 and from 407 to 690, respectively). CONCLUSIONS: A tight correlation is detected between immunovirologic improvement during HAART and down regulation of the X4/R5 ratio. Preliminary data suggest that increased IFN-gamma production could be responsible for the augmented expression of R5. While Ntr patients have an increasing plasma viremia and X4/R5 ratio, the decrease in X4/R5 ratio continues over time in patients with undetectable viral load and could represent a surrogate marker of prognostic value.

Publication Types:
  • Meeting Abstracts
  • Acquired Immunodeficiency Syndrome
  • Antigens, CD4
  • Antiretroviral Therapy, Highly Active
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes
  • HIV Infections
  • HIV Seropositivity
  • Humans
  • Receptors, CCR5
  • Receptors, CXCR4
  • Viral Load
  • Viremia
  • immunology
Other ID:
  • GWAIDS0029715
UI: 102269347

From Meeting Abstracts

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