Lung Tissue Research Consortium (LTRC)

Program Description

The LTRC is a resource program of the NHLBI that provides human lung tissues to qualified investigators for use in their research. The program enrolls donor subjects who are anticipating lung surgery, collects blood and extensive phenotypic data from the prospective donors, and then processes their surgical waste tissues for research use. Most donor subjects have interstitial fibrotic lung disease or COPD. A standardized protocol is followed to assure high quality and uniformity of the data and biospecimens, and tissue samples are processed to allow pathological study, immunohistochemistry, gene expression analyses, biomarker measurements, genetic analyses, and electron microscopy. Phenotypic data include clinical and pathological diagnoses, chest CT images, pulmonary function tests, exposure and symptom questionnaires, and exercise tests. The LTRC provides tissues and data to approved investigators free of charge, but the LTRC does not provide funding to support research.

The NHLBI Project Officer for the LTRC is Tom Croxton, Ph.D., M.D.

Related Websites

LTRC Public Site

Clinical Centers

• The Mayo Clinic
• University of Colorado
• University of Michigan
• University of Pittsburgh

Data Coordinating Center

• Clinical Trials & Surveys Corp.

Tissue Core Laboratory

• University of Colorado

Data Coordinating Center

• The Mayo Clinic.

Program Start and End Date

January 2004 to January 2009

Original Funding Announcement (FOA)

NHLBI-HR-04-08: Clinical Centers

NHLBI-HR-04-11: Data Coordinating Center

NHLBI-HR-04-09: Tissue Core Laboratory

NHLBI-HR-04-10: Radiology Core Laboratory