Appendix A: Biosafety

Scientists who receive specimens from the NHLBI Biologic Specimen Repository must be aware of and follow all applicable biosafety regulations related to the use of the specimens. The biosafety reference material and programs described below are provided as a courtesy to Repository users.

The following regulatory and safety standards and recommendations should be reviewed and the appropriate guidelines followed by all investigators who receive materials from the NHLBI Biologic Specimen Repository:

1. Biosafety in Microbiological and Biomedical Laboratories, 3rd Edition, HHS Publication No. (CDC) 93-8395, May 1993.
2. Occupational exposure to bloodborne pathogens; final rule. Federal Register 56:64175-64182, 1991.
3. Agent summary statement for human immunodeficiency virus and report on laboratory-acquired infection with human immunodeficiency virus. MMWR 37(S-4):1-22, 1988.
4. Update: universal precautions for prevention of transmission of human immunodeficiency virus, hepatitis B virus, and other bloodborne pathogens in health-care settings. MMWR 37(24):377-382, 387-388, 1988.
5. Public health service statement on management of occupational exposure to human immunodeficiency virus, including considerations regarding zidovudine postexposure use. MMWR 39(RR-1):1-14, 1990.

The World Health Organization publishes a biosafety manual that reviews the practices and procedures needed for safe handling of infectious materials in the laboratory. This manual lists national guidelines and codes of practice for various countries, which may be useful for those scientists developing their own standard procedures. Information on how to obtain this manual, Laboratory Biosafety Manual, 2nd edition (1993) may be obtained by writing Distribution and Sales, Office of Publications, WHO, 1211 Geneva 27 Switzerland.

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Specimens Collected

Study I D	Total		Aliquots Shipped 1999-2004
AAT	3051
ACCESS	49164		22514
ACT	4761
ACTG	76893
ARDS	49477		1578
CARDIA	8992
CSSCD	8321		4052
DASH	15287		918
DISC	8746		2629
FORTE	2914
GSR	1041199		5364
HHS	80269		1427
LAM	12091
Miscellaneous	12047
NGHS	11095
OMNI HEART STUDY	3960
P2C2	8939		4
PACS	54835
PANEL	14515
PARVO	4429		1020
PREMIER	21897
RADAR	405556		448
REDS	18700		28
REDS 2	881600		2118
REDS HHV8 PANELS	8512
SPECIAL	130373		1738
SRA	49199		619
TIMI	42540
TRAP	63411
TRIPPS	14401		380
TSS	232096		696
TTVINV	249831		17410
VAT	92733		4772
Grand Total	3681834		67715

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