Genetically Altered Animal Models
Related to Heart, Lung, Blood, or Sleep
Search the Animal
Models Database
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Welcome to the NHLBI Genetically Altered Animal
Models Web Page. Each entry in the database corresponds to a Medline article,
published in 1995 or later, that describes a genetically altered animal model
of a disease or condition related to the heart, lung, or blood, or a sleep
disorder. (Models developed for other purposes, but used for the first time to
study an NHLBI-related disease or condition, are also included.) Included for
each entry are: an indication of the general area of applicability (i.e.,
heart, lung, blood, and/or sleep), the gene manipulated, the type of
manipulation (i.e., transgenic, knockout, or "other") involved, the disease or
condition under study, and the kind of animal used. Each entry is linked to the
Medline abstract.
You can select any gene or disease/condition you are
interested in from the corresponding menu, or you can use the text search box
to search for a string of characters appearing anywhere in any field. The text
search strategy ensures that you receive all variations of a term.
Click on the arrow (in the Abstract column) of any
animal model retrieved to link to the corresponding Medline abstract. When you
are finished reading the abstract, close the window to return to the NHLBI
Animal Models Web Page.
This web page is updated periodically. If you would
like to suggest for inclusion a model that was developed (or used for the first
time) in 1995 or later to study a disease or condition related to the heart,
lung, or blood, or a sleep disorder, please send the complete citation for the
original article describing the model to the Animal Model Web Page Coordinator,
E-mail: (ss100g@nih.gov). The
NHLBI Programs for Genomic Applications (PGA) is a major initiative to advance
functional genomics research relevant to heart, lung, blood, and sleep health
and disorders. One of the primary missions of the NHLBI PGA program is to
develop resources and reagents for dissemination to the community of
investigators involved in NHLBI-related research areas. As these resources
become available (even before they are discussed in published Medline
articles), links to information about them and their availability and
distribution will be provided through the NHLBI Web site. Go to the
NHLBI Programs
for Genomic Applications Resources Web Page, and click on PGA Resources Web
site at the bottom of the page; then click on Animal Models and Phenotypes at
the top of the column on the left.
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