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Agenda

Addiction & Chemical Intolerance

NIEHS Conference - September 19 & 20, 2005
Research Triangle Park, NC



MONDAY, SEPTEMBER 19
INTRODUCTION
8:30 am Samuel Wilson, Deputy Director, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC
Welcome and Workshop Goals
FEATURED SPEAKER
8:45 am Ting-Kai Li, Director, National Institute on Alcohol Abuse and Alcoholism (NIAAA/NIH), Bethesda, MD
Alcohol Tolerance and Intolerance
TOXICANT-INDUCED LOSS OF TOLERANCE
9:20 am Claudia Miller, University of Texas Health Science Center at San Antonio, San Antonio, TX
Chemical Intolerance (Abdiction) and Addiction: Mirror Images?
ENVIRONMENTAL EXPOSURES
9:45 am Richard Corsi, University of Texas, Austin, TX
Human Exposure to Volatile Organic Compounds in Indoor Environments
10:10 am Robin Whyatt, Columbia University Medical Center, New York City, NY
Pesticides: Assessing Exposures and Health Risks
10:35 am Break
CLINICAL OBSERVATIONS AND PARALLELS
10:50 am William Meggs, Brody School of Medicine at East Carolina University, Greensville, NC
Chemical Intolerance and Addiction: The Longest Five Days
11:15 am Iris Bell, University of Arizona College of Medicine, Tucson, AZ
Individual Differences in Time-Dependent Sensitization:
Possible Links between Environmentally-Triggered Illnesses and Addiction
11:40 am Roland Griffiths, Johns Hopkins University, Baltimore, MD
Caffeine Dependence and Withdrawal
12:05 pm Lunch
1:00 pm Mark Gold, University of Florida McKnight Brain Institute, Gainesville, FL
Occupational Exposures and Drug Addiction
1:25 pm Robert Malcolm, Medical University of South Carolina Institute of Psychiatry, Charleston, SC
Consequences of Repeated Alcohol Detoxifications:
New Findings with Anticonvulsants to Treat Withdrawal Syndrome
1:50 pm Discussion
ANIMAL MODELS
2:15 pm George Breese, University of North Carolina School of Medicine, Bowles Center for Alcohol Studies, Chapel Hill, NC
Multiple Ethanol Withdrawals: A "Kindling"/Stress Hypothesis of Alcoholism
2:40 pm Terry Robinson, University of Michigan, Ann Arbor, MI
Persistent Effects of Psychostimulant Drugs on Brain and Behavior
3:05 pm Break
3:20 pm Scott Bowen, Wayne State University, Detroit, MI
Abuse of Inhalants: Implications for Chemical Intolerance
3:45 pm Barbara Sorg**, Washington State University College of Veterinary Medicine, Pullman, WA
Animal Model for Chemical Intolerance Using Low-level Formaldehyde and Pesticide Exposures
4:10 pm David Overstreet**, University of North Carolina at Chapel Hill, Bowles Center for Alcohol Studies, Chapel Hill, NC
Animal Model of Chemical Intolerance with Underlying Cholinergic Hypersensitivity
4:35 pm Discussion
5:00 pm Reception

*   Conference Chair
**   Conference Co-chair

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TUESDAY, SEPTEMBER 20
GENETICS/GENOMICS/PROTEOMICS
8:30 am Cornelia Baines and Gail McKeown-Eyssen, University of Toronto, ON, Canada
Case-control Study of Genotypes Associated with Chemical Intolerance:
CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR
8:55 am Tamara Phillips, Oregon Health & Science University, Portland, OR
Addiction Genetics: Narrowing the Candidates
9:20 am Kent Vrana, Penn State University, Hershey, PA
Genomics/Proteomics of Alcohol Responses
9:45 am

William Slikker, U.S. Food and Drug Administration, Jefferson, AR

Understanding the Role of Polymorphisms and Gene Expression in Drug Addiction: A Systems Biology Approach
10:10 am Discussion
10:30 am Break
NEUROINFORMATICS
10:45 am

Leonid Bunegin, University of Texas Health Science Center at San Antonio, San Antonio, TX

Cerebral Blood Flow in Addiction, Withdrawal, and Chemical Intolerance
11:10 am

Howard Hu, Harvard University School of Public Health, Boston, MA

SPECT Scans and Chemical Intolerance
11:35 am

Marc Potenza, Yale University School of Medicine, New Haven, CT

Common Neural Correlates Across Addictions
12:00 pm Discussion
12:20 pm Summation and Future Directions
1:00 pm Adjournment

*   Conference Chair
**   Conference Co-chair

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Last Reviewed: September 19, 2005