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Agenda
Polycystic Ovary Syndrome (PCOS)
September, 17 - 20, 2000
National Institute of Environmental Health Sciences
Research Triangle Park, NC
SESSION 1: OVERVIEW SESSION (Evening session at Hotel)
Session Chairperson: Jeff Chang
6:30 PM Welcome - ( Jerry Heindel and NIEHS Representative )
6:35 PM Introduction and set the stage ( Jeff Chang, overview
slide )
6:45 PM Historical Perspective - ( Joe Goldzieher )
7:20 PM Morphologic and Physiologic Correlates of the PCOS Ovary - ( Greg Erickson )
7:45 PM Ultrasound Examination of Polycystic and Multicystic
Ovaries - ( Didier Dewailly )
8:15-9:30 PM RECEPTION AT HOTEL
SESSION 1: OVERVIEW SESSION CONT'D (NIEHS)
8:15-9:00 AM Etiological Considerations for PCOS ( pending )
9:00-9:45 OPEN
9:45-10:00 BREAK
SESSION II: EPIDEMIOLOGY OF PCOS
Session Chairperson: Estella Parrott
10:00-10:35 Epidemiologic studies---what do they tell us? - ( David Guzick )
10:35-11:10 Premature Pubarche and Adolescent PCOS - ( Silvia Arslanian )
11:10-11:40 Immediate and Long Term Health Consequences - ( Caren Solomon )
11:40-12:10 Discussion
12:10-1:10 LUNCH
SESSION III: REPRODUCTIVE ABNORMALITIES
Session Chairperson: Linda Giudice
1:10-1:45 PM Altered Steroidogenesis in PCOS - ( Walter Miller )
1:45-2:20 Role of the Adrenal in PCOS - ( Ricardo Azziz )
2:20-2:55 Neuroendocrine Dysfunction in PCOS - ( John Marshall )
2:55-3:25 Discussion: Where is the primary defect? How are these defects related?
3:25-3:40 BREAK
SESSION IV: ANIMAL MODELS OF PCOS
Session Chairperson: Perry Blackshear
3:40-4:00 IRS-proteins coordinate nutrient homeostasis, growth
and reproduction - ( Morris White )
4:00-4:20 Prenatal Androgen Excess Mimics a Primary Defect in
Female Rhesus Monkeys - ( Dave Abbott )
4:20-4:40 Genetically Engineered models (John Nilson)
4:40-5:00 Discussion
7:00-9:00 RECEPTION AND POSTER SESSION (Hotel)
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SESSION V: METABOLIC ABNORMALITIES AND THEIR RELATIONSHIP TO PCOS
Session Chairperson: Bob Barbieri
8:00-8:30 AM Central Obesity and the Metabolic Syndrome - ( John
Brunzell )
8:30-9:00 Insulin resistance - ( Andrea Dunaif )
9:00-9:30 Beta cell dysfunction - ( David Ehrmann )
9:30-10:00 Cardiovascular/blood pressure - ( Robert Wild )
10:00-10:30 Endothelial dysfunction - ( Helmut Steinberg )
10:30-11:00 BREAK
11:00-12:00 Diagnostic Criteria: Panel and audience discussion - ( Andrea Dunaif, Jeff Chang )
12:00-1:00 LUNCH
SESSION VI: GENETICS AND ENVIRONMENTAL INFLUENCES
Session Chairperson: Jerry Heindel
1:00-1:30 PM Genetic approaches for complex genetic diseases-problems
and pitfalls - ( Richard Spielman )
1:30-2:00 Candidate gene analysis of PCOS - ( Margarit Urbanek )
2:00-2:30 Possible role of steroid enzyme defects in PCOS - ( Steve
Franks )
2:30-3:00 Ovulation induction: predictors of ovarian response
and clinical outcome - ( Bart Fauser )
3:00-3:30 BREAK
3:30-4:00 Role of Obesity in PCOS - ( Ann Taylor )
4:00-4:30 Role of the environment in PCOS - ( Claude
Hughes )
4:30-5:00 Genetic susceptibility and Gene-environment interactions
( pending )
5:00-5:30 Discussion
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SESSION VII: INTERVENTION/PREVENTION STRATEGIES ( NIEHS )
Session Chairperson: Sara Berga
8:30-9:10 AM Lifestyle modification - ( Rob Norman )
9:10-9:50 Metabolic Phenotyping - ( Rick Legro )
9:50-10:20 Break
10:20-10:50 Treatment of Hyperandrogenism - ( Roger Lobo )
10:50-11:20 Insulin Lowering Drugs as investigative tools and
therapy - ( John Nestler )
11:20-12:00 Discussion
SESSION VIII: SUMMARY AND FUTURE DIRECTIONS
12:00-1:00 Panel Discussion of where we are and future directions/needs - ( Andrea Dunaif, Jeff Chang, Claude Hughes, Mike McClure, Jerry Heindel, Estella Parrott, with the participation of all attendees )
1:00 Meeting ajourns
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