Agenda

Polycystic Ovary Syndrome (PCOS)

September, 17 - 20, 2000
National Institute of Environmental Health Sciences
Research Triangle Park, NC

Sunday, September 17

SESSION 1: OVERVIEW SESSION (Evening session at Hotel)

• Session Chairperson: Jeff Chang
• 6:30 PM Welcome - ( Jerry Heindel and NIEHS Representative )
• 6:35 PM Introduction and set the stage ( Jeff Chang, overview slide )
• 6:45 PM Historical Perspective - ( Joe Goldzieher )
• 7:20 PM Morphologic and Physiologic Correlates of the PCOS Ovary - ( Greg Erickson )
• 7:45 PM Ultrasound Examination of Polycystic and Multicystic Ovaries - ( Didier Dewailly )
• 8:15-9:30 PM RECEPTION AT HOTEL

Monday, September 18

SESSION 1: OVERVIEW SESSION CONT'D (NIEHS)

• 8:15-9:00 AM Etiological Considerations for PCOS ( pending )
• 9:00-9:45 OPEN
• 9:45-10:00 BREAK

SESSION II: EPIDEMIOLOGY OF PCOS

• Session Chairperson: Estella Parrott
• 10:00-10:35 Epidemiologic studies---what do they tell us? - ( David Guzick )
• 10:35-11:10 Premature Pubarche and Adolescent PCOS - ( Silvia Arslanian )
• 11:10-11:40 Immediate and Long Term Health Consequences - ( Caren Solomon )
• 11:40-12:10 Discussion
• 12:10-1:10 LUNCH

SESSION III: REPRODUCTIVE ABNORMALITIES

• Session Chairperson: Linda Giudice
• 1:10-1:45 PM Altered Steroidogenesis in PCOS - ( Walter Miller )
• 1:45-2:20 Role of the Adrenal in PCOS - ( Ricardo Azziz )
• 2:20-2:55 Neuroendocrine Dysfunction in PCOS - ( John Marshall )
• 2:55-3:25 Discussion: Where is the primary defect? How are these defects related?
• 3:25-3:40 BREAK

SESSION IV: ANIMAL MODELS OF PCOS

• Session Chairperson: Perry Blackshear
• 3:40-4:00 IRS-proteins coordinate nutrient homeostasis, growth and reproduction - ( Morris White )
• 4:00-4:20 Prenatal Androgen Excess Mimics a Primary Defect in Female Rhesus Monkeys - ( Dave Abbott )
• 4:20-4:40 Genetically Engineered models (John Nilson)
• 4:40-5:00 Discussion
• 7:00-9:00 RECEPTION AND POSTER SESSION (Hotel)

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Tuesday, September 19

SESSION V: METABOLIC ABNORMALITIES AND THEIR RELATIONSHIP TO PCOS

• Session Chairperson: Bob Barbieri
• 8:00-8:30 AM Central Obesity and the Metabolic Syndrome - ( John Brunzell )
• 8:30-9:00 Insulin resistance - ( Andrea Dunaif )
• 9:00-9:30 Beta cell dysfunction - ( David Ehrmann )
• 9:30-10:00 Cardiovascular/blood pressure - ( Robert Wild )
• 10:00-10:30 Endothelial dysfunction - ( Helmut Steinberg )
• 10:30-11:00 BREAK
• 11:00-12:00 Diagnostic Criteria: Panel and audience discussion - ( Andrea Dunaif, Jeff Chang )
• 12:00-1:00 LUNCH

SESSION VI: GENETICS AND ENVIRONMENTAL INFLUENCES

• Session Chairperson: Jerry Heindel
• 1:00-1:30 PM Genetic approaches for complex genetic diseases-problems and pitfalls - ( Richard Spielman )
• 1:30-2:00 Candidate gene analysis of PCOS - ( Margarit Urbanek )
• 2:00-2:30 Possible role of steroid enzyme defects in PCOS - ( Steve Franks )
• 2:30-3:00 Ovulation induction: predictors of ovarian response and clinical outcome - ( Bart Fauser )
• 3:00-3:30 BREAK
• 3:30-4:00 Role of Obesity in PCOS - ( Ann Taylor )
• 4:00-4:30 Role of the environment in PCOS - ( Claude Hughes )
• 4:30-5:00 Genetic susceptibility and Gene-environment interactions ( pending )
• 5:00-5:30 Discussion

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Wednesday, September 20

SESSION VII: INTERVENTION/PREVENTION STRATEGIES ( NIEHS )

• Session Chairperson: Sara Berga
• 8:30-9:10 AM Lifestyle modification - ( Rob Norman )
• 9:10-9:50 Metabolic Phenotyping - ( Rick Legro )
• 9:50-10:20 Break
• 10:20-10:50 Treatment of Hyperandrogenism - ( Roger Lobo )
• 10:50-11:20 Insulin Lowering Drugs as investigative tools and therapy - ( John Nestler )
• 11:20-12:00 Discussion

SESSION VIII: SUMMARY AND FUTURE DIRECTIONS

• 12:00-1:00 Panel Discussion of where we are and future directions/needs - ( Andrea Dunaif, Jeff Chang, Claude Hughes, Mike McClure, Jerry Heindel, Estella Parrott, with the participation of all attendees )
• 1:00 Meeting ajourns

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