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Selected Publications

Free Radical Metabolism Group

  1. Siraki, A.G., Deterding, L., Bonini, M.G., Jiang, J.J., Ehrenshaft, M., Mason, R.P. Procainamide but not N-acetylprocainamide induces protein free radical formation on myeloperoxidase: A potential mechanism of agranulocytosis. Chemical Research in Toxicology 21(5):1143-1153, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18489081) Exit NIEHS
  2. Rehman, H., Connor, H.D., Ramshesh, V.K., Theruvath, T.P., Mason, R.P. , Wright, G.L., Lemasters, J.J., Zhong, Z. Ischemic preconditioning prevents free radical production and mitochondrial depolarization in small-for-size rat liver grafts. Transplantation 85(9):1322-1331; 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18475191) Exit NIEHS
  3. Lardinois, O.M., Detweiler, C.D. , Tomer, K.B., Mason, R.P., Deterding, L.J. Identifying the site of spin trapping in proteins by a combination of liquid chromatography, ELISA and off-line tandem mass spectrometry. Free Radical Biology & Medicine 44(5):893-906; 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18160050) Exit NIEHS
  4. Bhattacharjee, S., Deterding, L.J., Jiang, J.J., Bonini, M.G., Tomer, K.B., Ramirez, D.C., Mason, R.P. Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis. Journal of the American Chemical Society 129(44):13493-13501; 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17939657) Exit NIEHS
  5. Jiang, J.J., Corbett, B.J., Hogg, N., Mason, R.P. An electron paramagnetic resonance investigation of the oxygen dependence of the arterial-venous gradient of nitrosyl hemoglobin (HbNO) in blood circulation. Free Radical Biology & Medicine 8:1208-1215; 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17854716) Exit NIEHS
  6. Bhattacharjee, S., Deterding, L.J., Jiang, J.J., Bonini, M.G., Tomer, K.B., Ramirez, D.C., Mason, R.P. Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis. Journal of the American Chemical Society 44:13493-13501; 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17939657) Exit NIEHS
  7. Ramirez, D.C., Gomez-Mejiba, S.E., Mason, R.P. Immuno-spin trapping analyses of DNA radicals. Nature Protocols 2:512-522; 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17406615&query_hl=16&itool=pubmed_docsum) Exit NIEHS
  8. Bonini, M.G., Siraki, A.G., Bhattacharjee, S., Mason, R.P. Glutathione-induced radical formation on lactoperoxidase does not corelate with the enzyme’s peroxidase activity. Free Radical Biol. Med. 42:985-992; 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17349926&query_hl=10&itool=pubmed_docsum) Exit NIEHS
  9. Bonini, M.G., Siraki, A.G., Atanassov, B.S., Mason, R.P. Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes. Free Radical Biol. Med. 42:530-540; 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17275685&query_hl=10&itool=pubmed_docsum) Exit NIEHS
  10. Woods, C.G., Burns, A.M., Maki, A., Bradford, B.U., Cunningham, M.L., Connor, H.D., Kadiiska, M.B., Mason, R.P., Peters, J.M., Rusyn, I. Sustained formation of α-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-α, but not NADPH oxidase. Free Radical Biol. Med. 42:335-342; 2007.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17210446&query_hl=7&itool=pubmed_docsum) Exit NIEHS
  11. Zhong, Z., Connor, H.D., Li, X., Mason, R.P., Forman, D.T., Lemasters, J.J., Thurman, R.G. Reduction of ciclosporin and tacrolimus nephrotoxicity by plant polyphenols. J. Pharm. Pharmacol. 58:1533-1543; 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17132217&query_hl=2&itool=pubmed_docsum) Exit NIEHS
  12. Kono, H., Woods, C.G., Maki, A., Connor, H.D., Mason, R.P., Rusyn, I., Fujii, H. Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. Free Rad. Res. 40:579-588; 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16753835) Exit NIEHS
  13. Ehrenshaft, M., Mason, R.P. Protein radical formation on thyroid peroxidase during turnover as detected by immuno-spin trapping. Free Radical Biol. Med. 41: 422-430; 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16843823) Exit NIEHS
  14. Nakai, K., Kadiiska, M.B., Jiang, J.-J., Stadler, K., Mason, R.P. Free Radical production requires both inducible nitric oxide synthase and xanthine oxidase in LPS-treated skin. Natl. Acad. Sci. USA.103: 4616-4621; 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16537416) Exit NIEHS
  15. Bonini, M.G., Rota, C., Tomasi, A., Mason, R.P. The oxidation of 2’,7’-dichlorofluorescin to reactive oxygen species: A self-fulfilling prophesy? Free Radical Biol. Med. 40: 968- 975; 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16540392) Exit NIEHS
  16. Keszler, A., Mason, R.P., Hogg, N. Immuno-spin trapping of hemoglobin and myoglobin radicals from nitrite-mediated oxidation. Free Radical Biol. Med. 40: 507-515; 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16443166) Exit NIEHS
  17. Ramirez, D.C., Gomez Mejiba, S.E., Mason, R.P. Immuno-spin trapping of DNA radicals. Nature Methods 3 (2): 123-127; 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16432522) Exit NIEHS
  18. Nakai, Kozo and Mason, R.P. Immunochemical detection of nitric oxide and nitrogen dioxide trapping of the tyrosyl radical and the resulting nitrotyrosine in sperm whale myoglobin. Free Radical Biol. Med. 39:1050-1058; 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16198232) Exit NIEHS
  19. Ramirez D.C., Gomez Mejiba S.E., Mason R.P. Copper-catalyzed protein oxidation and its modulation by carbon dioxide: enhancement of protein radicals in cells. J. Biol. Chem. 280: 27402-27411; 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15905164) Exit NIEHS
  20. Zhong Z., Conner H.D., Frosh M., Bunzedahl H., Lind H., Lehnert M., Mason R.P., Thurman R.G., Lemasters J.J. Free radical-dependent dysfunction of small-for-size rat liver grafts: prevention by plant polyphenols. Gastroenterology 129: 652-664; 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16083719) Exit NIEHS
  21. Dikalov S., Jiang J., Mason R.P. Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Analysis of conformation exchange. Free Radic. Res. 39(8): 825-836; 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16036362) Exit NIEHS
  22. Detweiler C.D., Lardinois O.M., Deterding L.J., Ortiz de Montellano P.R., Tomer K.B., Mason R.P. Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization. Free Radic. Biol. Med. 38: 969-976; 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15749393) Exit NIEHS
  23. Arimoto T., Kadiiska M.B., Sato K., Corbett J., Mason R.P. Synergistic production of lung free radicals by diesel exhaust particles and endotoxin. Am. J. Respir. Crit. Care Med. 171: 379-387, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15477498) Exit NIEHS
  24. Kadiiska, M.B., Gladen, B.C., Baird, D.D., Graham, L.B., Parker, C.E., Ames, B.N., Basu, S., FitzGerald, G.A., Lawson, J.A., Marnett, L.J., Morrow, J.D., Murray, D.M., Plastaras, J., Roberts, L.J., Rokach, J., Shigenaga, M.K., Sun, J., Walter, P.B., Tomer, K.B., Barrett, J.C., Mason, R.P. Biomarkers of Oxidative Stress Study III. Effects of the Non-Steroidal Anti-Inflammatory Agents Indomethacin and Meclofenamic acid on Measurements of Oxidative Products of Lipids in CCl4 Poisoning. Free Radical Biol. Med. 38: 711-718, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15721981) Exit NIEHS
  25. Kadiiska, M.B., Gladen, B.C., Baird, D.D., Germolec, D., Graham, L.B., Parker, C.E., Nyska, A., Wachsman, J.T., Ames, B.N., Basu, S., Brot, N., FitzGerald, G.A., Floyd, R.A., George, M., Heinecke, J.W., Hatch, G.E., Hensley, K., Lawson, J.A., Marnett, L.J., Morrow, J.D., Murray, D.M., Plastaras, J., Roberts, L.J., Rokach, J., Shigenaga, M.K., Sohal, R.S., Sun, J., Tice, R.R., Van Thiel, D.H., Wellner, D., Walter, P.B., Tomer, K.B., Mason, R.P., Barrett, J.C. Biomarkers of Oxidative Stress Study II. Are Oxidation Products of Lipids, Proteins and DNA Markers in CCl4 Poisoning? Free Radical Biol. Med. 38: 698-710, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15721980) Exit NIEHS
  26. Ramirez, D.C., Gomez Mejiba, S.E., Mason, R.P. Mechanism of hydrogen peroxide-induced Cu, Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping. Free Radical Biol. Med. 38: 201-214, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15607903) Exit NIEHS
  27. Qian, S.Y., Kadiiska M.B., Guo, Q., Mason R.P. A novel protocol to identify and quantify all spin trapped free radicals from in vitro/in vivo interaction of HO• and DMSO: LC/ESR, LC/MS, and dual spin trapping combinations. Free Radic. Biol. Med. 38: 125-135, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15589381) Exit NIEHS
  28. Connor HD, Sturgeon BE, Mottley C, Sipe HJ, Mason RP. L-tryptophan radical cation electron spin resonance studies: connecting solution-derived hyperfine coupling constants with protein spectral interpretations. J Am Chem Soc. 130: 6381-6387, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18433127) Exit NIEHS
  29. Bonini MG, Stadler K, Silva SO, Corbett J, Dore M, Petranka J, Fernandes DC, Tanaka LY, Duma D, Laurindo FRM, Mason RP. Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation. Proceedings of the National Academy of Sciences of the United States of America 105(25):8569-8574, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18562300) Exit NIEHS

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Last Reviewed: September 03, 2008