What Causes Pulmonary Arterial Hypertension?
Certain factors appear to increase your chances of
developing pulmonary arterial hypertension (PAH). They include:
- Use of appetite suppressants, especially
fenfluramine (fen-FLOO-ra-men) and dexfenfluramine (deks-fen-FLOO-ra-men)
- Chronic use of cocaine or amphetamines
- HIV infection
- Liver disease
- Connective tissue diseases, such as
scleroderma or
lupus erythematosus
Doctors do not know what causes
primary pulmonary arterial hypertension
(PPAH), although it is inherited in some people. Recently, researchers
discovered a defect in a gene that can lead to changes in the pulmonary
arteries like those seen in PPAH. They think that other genes may be involved
as well. As we learn more about how different genes work in the development of
PPAH, better treatments and perhaps a preventive treatment or cure will be
found.
Secondary pulmonary
arterial hypertension (SPAH) is caused by a variety of conditions.
Chronic
obstructive pulmonary disease is the most common cause in adults.
Other Conditions That Can Lead to SPAH
PAH affects men and women of all ages, from very
young children to seniors, and people of all racial and ethnic backgrounds.
PPAH is most common in women in their thirties and
men in their forties. Twice as many cases are reported in women as in men.
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