Table 1. Birth Defects Studied in the National Birth Defects Prevention Study by System Affected

System Affected                     Birth Defects Studied
Cardiovascular Conotruncal heart defects, septal heart defects, obstructive heart defects, atrioventricular septal defects, single ventricle, anomalous pulmonary venous return, heterotaxy, Ebstein malformation
Central nervous system Neural tube defects, hydrocephaly, holoprosencephaly, Dandy-Walker malformation
Eye Anophthalmia/microphthalmia, congenital cataracts, glaucoma
Ear Anotia/microtia
Orofacial Choanal atresia, cleft lip, cleft palate
Gastrointestinal Esophageal atresia and tracheoesophageal fistula, intestinal atresia, biliary atresia
Genitourinary Renal agenesis (bilateral), hypospadias (2nd or 3rd degree)
Musculoskeletal Diaphragmatic hernia, gastroschisis, omphalocele, limb deficiency, craniosynostosis, bladder exstrophy, cloacal exstrophy, sacral agenesis/caudal regression
Non-system-specific                 Amniotic band sequence

June 17, 2005