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aprepitant![Patient Information Patient Information](https://webarchive.library.unt.edu/eot2008/20081010110018im_/http://cancernet.nci.nih.gov/images/btn-patient-info.gif) A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081010110018im_/http://cancernet.nci.nih.gov/images/spacer.gif) | Emend | | ![](https://webarchive.library.unt.edu/eot2008/20081010110018im_/http://cancernet.nci.nih.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20081010110018im_/http://cancernet.nci.nih.gov/images/spacer.gif) | L-754030 MK-0869 ONO-7436 | | ![](https://webarchive.library.unt.edu/eot2008/20081010110018im_/http://cancernet.nci.nih.gov/images/spacer.gif) |
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