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ketoconazole A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand names: | | Nizoral Xolegel | | | Foreign brand names: | | Fungarest Fungoral Ketoderm Ketoisdin Orifungal M Panfungol | | | Abbreviation: | | KCZ | | | Code name: | | R-41400 | | | Chemical structure name: | | cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine | | |
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