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Program Initiatives

The research funded by DAB can be divided into 3 main areas, covered by the respective portfolios, as well as the Shock Centers and training.

Genetics and Cell Biology Branch

The Genetics and Cell Biology Branch focuses on the basic molecular mechanisms believed to underlie age-related dysfunction, with a focus on molecular studies, performed primarily in cell culture and model organisms.
Research supported by this branch includes genetic manipulations that affect the length and/or quality of life, as well as molecular and cellular mechanisms including mitochondrial dysfunction, cell senescence, changes in gene expression/signal transduction, DNA damage and repair, stress responses and protein homeostasis.

Aging Physiology Branch

The Aging Physiology Branch focuses on age-related changes affecting tissue and organ function.  Research supported includes fundamental mechanisms of altered function in tissues and organs that result from aging or contribute to conditions and diseases of aging. Research is supported at molecular, cellular and higher levels of organization including integration across tissues and organ systems. The Aging Physiology Branch coordinates support for stem cell and translational research.

Resources Branch

The Biological Resources Branch focuses on the identification, development and characterization of new animal models — both mammalian and invertebrate — for use in aging research. In addition, this Branch manages and maintains the biological resources needed to support aging research, including both rodent colonies and tissue banks.

Currently available resources can be found at

Page last updated May 30, 2008