Chemokine Receptors in the Differentiation of Human CD4+ Effector/Memory T Cells |
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Launch in standalone player | |
Air date: | Wednesday, June 18, 2008, 4:15:00 PM |
Category: | Immunology |
Description: | Josh Farber's research has focused on lymphocyte-active chemokines and their receptors. In early work, his laboratory discovered the major Th1 chemokine CXCL9 (Mig) and several critical T cell chemokine receptors, including CCR6, CXCR6, and CCR9A/B. In 1997, in collaboration with Ed Berger and Keith Peden, he showed that CXCR6 is a coreceptor for SIV and certain strains of HIV. In more recent work he has been investigating
chemokine receptor signaling and the epigenetics of chemokine receptor expression on human lymphocytes, and using chemokine receptor patterns to study the differentiation of human CD4+ effector/memory T cells. The latter studies have revealed that CCR5 and CCR2 identify subsets of potentially long-lived, highly differentiated effector memory T cells, so-called first responders, and that CCR6 is the chemokine receptor found on all Th17 cells. Currently, his laboratory is investigating the
importance of CCR6 in models of Th17-mediated disease. Come hear about these and other exciting findings from one of NIH's own. For more information, visit The Immunology Interest Group |
Author: | Joshua Farber, M.D., Senior Investigator, Chief Inflammation Biology Section Laboratory of Molecular Immunology NIAID, NIH |
Runtime: | 00:59:27 |
Download: | Download
Video How to download a Videocast |
CIT File ID: | 14566 |
CIT Live ID: | 6739 |
Permanent link: | http://videocast.nih.gov/launch.asp?14566 |