Chemokine Receptors in the Differentiation of Human CD4+ Effector/Memory T Cells
 


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Air date: Wednesday, June 18, 2008, 4:15:00 PM
Category: Immunology
Description: Josh Farber's research has focused on lymphocyte-active chemokines and their receptors. In early work, his laboratory discovered the major Th1 chemokine CXCL9 (Mig) and several critical T cell chemokine receptors, including CCR6, CXCR6, and CCR9A/B. In 1997, in collaboration with Ed Berger and Keith Peden, he showed that CXCR6 is a coreceptor for SIV and certain strains of HIV. In more recent work he has been investigating chemokine receptor signaling and the epigenetics of chemokine receptor expression on human lymphocytes, and using chemokine receptor patterns to study the differentiation of human CD4+ effector/memory T cells. The latter studies have revealed that CCR5 and CCR2 identify subsets of potentially long-lived, highly differentiated effector memory T cells, so-called first responders, and that CCR6 is the chemokine receptor found on all Th17 cells. Currently, his laboratory is investigating the importance of CCR6 in models of Th17-mediated disease. Come hear about these and other exciting findings from one of NIH's own.

For more information, visit
The Immunology Interest Group
Author: Joshua Farber, M.D., Senior Investigator, Chief Inflammation Biology Section Laboratory of Molecular Immunology NIAID, NIH
Runtime: 00:59:27
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CIT File ID: 14566
CIT Live ID: 6739
Permanent link: http://videocast.nih.gov/launch.asp?14566