Genes and Genome Systems Cluster

PROGRAM GUIDELINES

A revised version of the NSF Proposal & Award Policies & Procedures Guide (PAPPG), NSF 09-1, was issued on October 1, 2008 and is effective for proposals submitted on or after January 5, 2009. Please be advised that the guidelines contained in NSF 09-1 apply to proposals submitted in response to this funding opportunity.  Proposers who opt to submit prior to January 5^th, 2009, must also follow the guidelines contained in NSF 09-1.

One of the most significant changes to the PAPPG is implementation of the mentoring provisions of the America COMPETES Act.  Each proposal that requests funding to support postdoctoral researchers must include, as a separate section within the 15-page project description, a description of the mentoring activities that will be provided for such individuals.  Proposals that do not include a separate section on mentoring activities within the Project Description will be returned without review (see the PAPP Guide Part I: Grant Proposal Guide Chapter II.C.2.d for further information).

Apply to PD 04-1112 as follows:

For full proposals submitted via FastLane: standard Grant Proposal Guidelines apply.
For full proposals submitted via Grants.gov: NSF Grants.gov Application Guide; A Guide for the Preparation and Submission of NSF Applications via Grants.gov Guidelines apply (Note: The NSF Grants.gov Application Guide is available on the Grants.gov website and on the NSF website at: http://www.nsf.gov/bfa/dias/policy/docs/grantsgovguide.pdf)

DUE DATES

SYNOPSIS

The Genes and Genome Systems Cluster supports studies on genomes and genetic mechanisms in all organisms, whether prokaryote, eukaryote, phage, or virus. Proposals on the structure, maintenance, expression, transfer, and stability of genetic information in DNA, RNA, and proteins and how those processes are regulated are appropriate. Areas of interest include genome organization, molecular and cellular evolution, replication, recombination, repair, and vertical and lateral transmission of heritable information. Of equal interest are the processes that mediate and regulate gene expression, such as chromatin structure, epigenetic phenomena, transcription, RNA processing, editing and degradation, and translation. The use of innovative in vivo and/or in vitro approaches, including biochemical, physiological, genetic, genomic, and/or computational methods, is encouraged, as is research at the interfaces of biology, physics, chemistry, mathematics and computer science, and engineering.

Program Directors:

Patrick Dennis.   Prokaryotic genetics, genomics and gene regulation; Structure, function and dynamics of DNA, RNA and nucleic acid-protein complexes; Ribosome structure, function and assembly; Synthetic biology; Phage

Susan Porter Ridley.  Eukaryotic genetics and genetic mechanisms, including those involving prions; Molecular aspects of population genetics; Molecular evolution of eukaryotes.

Jo Ann Wise.  Mechanisms and regulation of gene expression from RNA synthesis to processing and turnover; Epigenetic regulation including biogenesis and function of non-coding RNAs and RNA interference; Viral RNA replication and translational regulation.

Michael K. Reddy.  Eukaryotic DNA replication, repair, and recombination; Chromosome structure and function; Molecular evolution; Eukaryotic viruses; and Plant genetics.

Susanne von Bodman.  Genetics and molecular and cellular biology of prokaryotes and plants; Gene expression and regulatory networks; Microbial development; RNA-based gene regulation; Horizontal gene transfer.

Abstracts of Recent Awards Made Through This Program