National Institute on Aging National Institutes of Health

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Julie A. Mattison, Ph.D., Facility Head NIA Primate Aging Studies Behavioral Neuroscience Section Laboratory of Experimental Gerontology E-mail: mattisonj@mail.nih.gov

Education

1990 - B.S., University of California, San Diego 1993 - M.S., Central Washington University 2000 - Ph.D., Southern Illinois University 2000 - IRTA Fellow, National Institute on Aging

Chronology of Employment

1995-2000 - Teaching Assistant, Dept. of Physiology, Southern Illinois University 1997-2000 - Course Instructor, The Princeton Review, St. Louis, MO 1997-2000 - Research Assistant, Dept. of Physiology, Southern Illinois University 2000-2003 - Postdoctoral IRTA Fellow, National Institute on Aging, Baltimore, MD 2000-2004 - Lecturer and Adjunct Professor, College of Notre Dame of Maryland, Baltimore, MD 2004-2006 - Contract Facility Head, National Institute on Aging, Baltimore, MD 2006-Present - Staff Scientist/Facility Head, National Institute on Aging, Baltimore, MD

Societies

American Aging Association, 1999Board of Directors, 2004-Present Fellow, 2005

Awards

American Aging Association, Walter R. Nicolai Award, 1999 American Aging Association, Paul Glenn Award, 2002

Publications

Debeljuk, L., Steger, R.W., Wright, J.C., Mattison, J.A., Bartke, A. Effects of overexpression of growth hormone-releasing hormone on the hypothalamo-pituitary-gonadal function in the mouse. Endocrine 11:171-179, 1999. Bartke, A., Chandrashekar, V., Turyn, D., Steger, R.W., Debeljuk, L., Winters, T.A., Mattison, J.A., Danilovich, N.A., Croson, W., Wernising, D.R., Kopchick, J.J. Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice. Proceedings for the Society of Experimental Biology and Medicine 222:113-123, 1999. Mattison, J.A., Wright, J.C., Bronson, R.T., Roth, G.S., Ingram, D.K., Bartke, A. Studies of aging in Ames dwarf mice: effects of caloric restriction. Journal of the American Aging Association 23:9-16, 2000. Mattison, J.A. Ames dwarf mice: a model for delayed aging. Advances in Gerontology 4:141-146, 2000. Bartke, A., Brown-Borg, H., Kinney, B., Mattison, J., Wright, C., Hauck, S., Coschigano, K., Kopchick, J. Growth hormone and aging. Journal of the American Aging Association 23:219-225, 2000. Bartke, A., Brown-Borg, H., Mattison, J., Kinney, B., Hauck, S., Wright, C. Prolonged longevity of hypopituitary dwarf mice. Experimental Gerontology. 36:21-28, 2001. Bartke, A., Coschigano K., Kopchick, J., Chandrashekar, V., Mattison, J., Kinney, B., Hauck, S. Genes that prolong life: Relationships of growth hormone and growth to aging and life span. J. Gerontology: Biological Sciences 56A:B340-B349, 2001. Mattison, J.A., Roth, G.S., Ingram, D.K., Lane, M.A. Endocrine effects of dietary restriction and aging: The National Institute on Aging study. Journal of Anti-Aging Medicine 3:215-223, 2001. Bartke, A., Wright, J.C., Mattison, J.A., Ingram, D.K., Miller, R.A, Roth, G.S. Extending the lifespan of long-lived mice. Nature 414:412, 2001. Bartke, A., Wright, J.C., Mattison, J.A., Ingram, D.K., Miller, R.A, Roth, G.S. Dietary restriction and life-span. Science 296:2141, 2002. Roth, G.S., Lane, M.A., Ingram, D.K., Mattison, J.A., Elahi, D., Tobin, J., Muller, D., Metter, E.J. Physiological markers of dietary caloric restriction in animals predict longevity in a human population. Science 297:811, 2002. Roth, G.S., Handy, A.M., Mattison, J.A., Tilmont, E.M., Ingram, D.K., Lane, M.A. Effects of dietary caloric restriction and aging on thyroid hormones of rhesus monkeys. Hormones and Metabolic Research 34:378-382, 2002. Srivastava, V.K., Dearth, R.K., Hiney, J.K., Chandrashekar, V., Mattison, J.A., Bartke, A., Dees, W.L. Alcohol suppresses insulin-like growth factor-1 gene expression in prepubertal transgenic female mice overexpressing the bovine growth hormone gene. Alcoholism: Clinical and Experimental Research 26:1697-1702, 2002. Lane, M.A., Mattison, J., Ingram, D.K., Roth, G.S. Caloric restriction and aging in primates: relevance to humans and possible CR mimetics. Microscopy Research and Technique 59:335-338, 2002. Mattison, J.A., Lane, M.A., Roth, G.S., Ingram, D.K. Calorie restriction in rhesus monkeys. Experimental Gerontology 38:35-46, 2002. Heiman, M.L., Tinsley, F.C., Mattison, J.A., Hauck, S., Bartke, A. Body composition of prolactin-, growth hormone-, and thyrotropin-deficient Ames dwarf mice. Endocrine 20:149-154, 2003. Sell, D.R., Lane, M.A., Obrenovich, M.E., Mattison, J.A., Handy, A., Ingram, D.K., Cutler, R.G., Roth, G.S., Monnier, V.M. The effect of caloric restriction on glycation and glycoxidation in skin collagen of nonhuman primates. Journal of Gerontology: Biological Sciences 58A:508-516, 2003. Torre III, P., Mattison, J.A., Fowler, C.G., Lane, M.A., Roth, G.S., Ingram, D.K. Assessment of auditory function in rhesus monkeys (Macaca mulatta): Effects of age and calorie restriction. Neurobiology of Aging 25:945-954, 2004. Matochik, J.A., Chefer, S.I., Ingram D.K., Roth, G.S., Mattison, J.A., London, E.D., Lane, M.A. Age-related decline in striatal volume in rhesus monkeys: Assessment of long-term calorie restriction. Neurobiology of Aging 25:193-200, 2004. Ingram, D.K., Anson, R.M., de Cabo R., Mamczarz, J., Zhu, M., Mattison, J., Lane, M.A., Roth, G.S. Development of calorie restriction meimetics as a prolongevity strategy. Annals of New York Academy of Sciences 1019:1-12, 2004. Lane, M.A, Mattison, J.A., Roth, G.S., Brant, L.J., Ingram, D.K. Effects of long-term diet restriction on aging and longevity in primates remain uncertain. Journal of Gerontology: Biological Sciences 59A:405-407, 2004. Lane, M.A., de Cabo, R., Mattison, J., Anson, R.M., Roth, G.S., Ingram, D.K. The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics. Experimental Gerontology 39:897-902, 2004. Urbanski, H.F., Downs, J.L., Garyfallou, V.T., Mattison, J.A., Lane, M.A., Roth, G.S., Ingram, D.K. Effect of caloric restriction on the 24-hour plasma DHEAS and cortisol profiles of young and old male rhesus macaques. Annals of New York Academy of Sciences 1019:443-447, 2004. Roth, G.S., Mattison, J.A., Ottinger, M.A., Chachich, M.E., Lane, M.A., Ingram, D.K. Aging in rhesus monkeys: Relevance to human health interventions. Science 305:1423-1426, 2004. Maswood, N., Young, J.E., Tilmont, E.M., Zhang, Z., Gash, D.M., Gerhardt, G.A., Grondin, R., Roth, G.S., Mattison, J.A., Lane, M.A., Carson, R.E., Cohen, R.M., Mouton, P.R., Quigley, C., Mattson, M.P., and Ingram, D.K.: Calorie restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc. Nat. Acad. Sci. 101:18171-18176, 2004. Mattison, J.A., Black, A., Huck, J., Moscrip, T., Handy, A., Tilmont, E., Roth, G.S., Lane, M.A., Ingram, D.K. Age-related decline in caloric intake and motivation for food in rhesus monkeys. Neurobiology of Aging 26(7):1117-1127, 2005. Mattison, J.A., Croft, M.A., Dahl, D.B., Roth, G.S., Lane, M.A., Ingram, D.K., Kaufman, P.L. Accommodative function in rhesus monkey: effects of aging and calorie restriction. AGE 27:1-9, 2005. Ingram, D.K., Roth, G.S., Lane, M.A., Ottinger, M.A., Zou, S., de Cabo, R., Mattison, J.A.: The potential for dietary restriction to increase longevity in humans: extrapolation from monkey studies. Biogerontol. 7(3):143-148, 2006. Messaoudi, I., Warner, J., Fischer, M., Park, B., Hill, B., Mattison, J., Lane, M.A., Roth, G.S., Ingram, D.K., Picker, L.J., Douek, D.C., Mori, M., Nikolich-Zugich, J. Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates. Proc. Nat. Acad. Sci. 103:19448-19453, 2006. Qin, W., Chachich, M., Lane, M., Roth, G., Bryant, M., de Cabo, R., Ottinger, M.A., Mattison, J., Ingram, D., Gandy, S., Pasinetti, G.M. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in squirrel monkeys (Saimiri sciureus). J. Alzheimer's Dis. 10:417-422, 2006. Perry, T.A., Holloway, H.W., Weerasuriya, A., Mouton, P.R., Duffy, K., Mattison, J.A., Greig, N.H. Evidence of GLP-1 mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp. Neurol. 203:293-301, 2007. Ingram, D.K., Young, J., Mattison, J.A. Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging. J. Neuroscience. 145:1359-1364, 2007. Srivastava, V.K., Hiney, J.K., Mattison, J.A., Bartke, A., Dees, W.L. The alcohol-induced suppression of ovarian insulin-like growth factor-1 gene transcription is independent of growth hormone and its receptor. Alcoholism: Clin. Exper. Res. 31:880-886, 2007. Moore, C.M., Dunn, B.G., McMahan, C.A., Lane, M.A., Roth, G.S., Ingram, D.K., Mattison, J.A. Effects of caloric restriction on chromosomal stability in rhesus monkeys (Macaca mulatta). AGE: J. Am. Aging Assoc. 29:15-28, 2007. Downs, J.L., Mattison, J.A., Ingram, D.K., Urbanski, H.F. Effect of age and caloric restriction on circadian adrenal steroid rhythms in rhesus macaques. Neurobiol. Aging (in press). Mattison, J.A., Ottinger, M.A., Powell, D., Longo, D.L., Ingram, D.K. Endometriosis: clinical monitoring and treatment procedures in rhesus monkeys. J. Med. Primatol. (in press).

Book Chapters

Mattison, J.A., Ingram, D.K., Roth, G.S., Lane, M.A. Nutritional modulation of aging by caloric restriction. In Erwin J.M. and Hof P.R. (eds): Aging in Nonhuman Primates. Vol 31, pp. 63-75. Basel, Karger, 2002.

Ingram, D.K., de Cabo, R., Anson, M., Ottinger, M.A., Lane, M.A., Roth, G.S., Mattison, J.A. Calorie restriction in nonhuman primates: impact on aging, disease, and frailty. In Carey et al. (eds): Longevity and Frailty, pp. 39-56. Springer-Verlag, Berlin Heidelberg, 2005.

Ottinger, M.A., Mattison, J.A., Zelinski, M.B., Wu, J.M., Kohama, S.G., Roth, G.S., Lane, M.A., Ingram, D.K. The rhesus macaque as a model of human aging and age-related disease. In Conn, P.M. (ed): Handbook of Models for Human Aging, Academic Press, pp. 457-468.

Mattison, J.A., Roth, G.S., Lane, M.A., Ingram, D.K.: Dietary restriction in aging nonhuman primates. In: Mobbs, C.V., Yen, K., Hof, P.R., (Eds): Mechanisms of Dietary Restriction in Aging and Disease. Interdisciplinary Topics in Gerontology. Volume 35. Basel, Karger, 2007, pp. 137-158.

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