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The CSB investigated a reactive chemical explosion at the First Chemical Corp. facility in Pascagoula, MS. The investigation found that the First Chemical facility did not have an adequate management system for evaluating the hazards of processing MNT, an explosive material. Furthermore, the facility did not have an adequate system for ensuring sufficient layers of protection, consistent work practices when isolating equipment, and the integrity of isolation valves. The investigation also found that the control room construction and its proximity to the process was not evaluated, and that the community emergency notification system was inadequate. The CSB issued safety recommendations based on these root and contributing causes.