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March 24, 2005

  In This Issue:
bullet Noisy Pictures Tell a Story of 'Entangled' Atoms
bullet Billions in Cost Estimated for Firefighter Injuries
bullet Where's Waldo's DNA? New NIST SRM Joins Search
  Quick Links:
bullet HIV/AIDS Structure Database Is a Hit with Researchers
bullet New Facility Recognized in Lab Design Competition
bullet Fire Retardant Foam Consortium to Meet
bullet How Long Should Digital Storage Media Last?
bullet NIST, Utah State Collaborate on Sensor Technology

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Noisy Pictures Tell a Story of 'Entangled' Atoms

Similar patterns of "noise" are evident in these two images. The images are taken directly after molecules have been split into entangled atom pairs. Each of the pictures shows the absorption of laser light by potassium atoms in one out of two different energy states. High concentrations of atoms absorbing light are circled in yellow, and areas with fewer atoms are circled in green. The similar pattern in the two images directly shows the correlation between atoms in the different states.

Similar patterns of "noise" are evident in these two images. The images are taken directly after molecules have been split into entangled atom pairs. Each of the pictures shows the absorption of laser light by potassium atoms in one out of two different energy states. High concentrations of atoms absorbing light are circled in yellow, and areas with fewer atoms are circled in green. The similar pattern in the two images directly shows the correlation between atoms in the different states.

Click here to download a higher resolution version of this image.

Patterns of noise—normally considered flaws—in images of an ultracold cloud of potassium provide the first-ever visual evidence of correlated ultracold atoms, a potentially useful tool for many applications, according to physicists at JILA, a joint institute of the National Institute of Standards and Technology (NIST) and the University of Colorado at Boulder.

Described in the March 21 online issue of Physical Review Letters,* the noise analysis method could, in principle, be used to identify and test the limits of entanglement, a phenomenon Einstein called “spooky action at a distance.” With entangled atom pairs, for example, the properties of one atom instantaneously affect the properties of its mate, even when the two are physically separated by substantial distances. Such tests of the basic rules of quantum physics could be helpful, for example, in efforts to design quantum computers that would use the properties of individual neutral atoms as 1s and 0s for storing and processing data.

The method demonstrated at JILA also could enable scientists to “see,” for the first time, other types of correlations between atoms in fermionic condensates, a new quantum state first created by the same JILA research group (see www.nist.gov/public_affairs/releases/fermi_condensate.htm), in which thousands of pairs of atoms behave in unison. And it could perhaps be applied in highly sensitive measurement techniques using beams of entangled atoms.

“There are a number of interesting quantum states that are not obviously seen if you just take a picture,” says Deborah Jin of NIST, leader of the research group that developed the new method and also previously created fermionic condensates. “A Fermi condensate, for example, would not show up in an ordinary image. However, correlations between atoms should actually show up in the noise in these images.”

Ultracold molecules (center) are split into entangled pairs of atoms flying apart in opposite directions. A laser beam (left) is used to create shadow images of the cloud (right). The pairs of entangled atoms can then be found by carefully studying the noise pattern in these pictures. (credit: Markus Greiner/JILA)
Ultracold molecules (center) are split into entangled pairs of atoms flying apart in opposite directions. A laser beam (left) is used to create shadow images of the cloud (right). The pairs of entangled atoms can then be found by carefully studying the noise pattern in these pictures.

(credit: Markus Greiner/JILA)

Click here to download a higher resolution version of this image.

The noise appears as speckles in images of a cloud of ultracold potassium atoms made under very specific conditions. This noise is not random, as would be expected ordinarily, but rather appears in duplicate patterns suggesting, although not proving, that pairs of atoms are entangled with each other—even when separated by as much as 350 micrometers. (For comparison, a human hair is about 70 micrometers wide.)

For further information, see www.nist.gov/public_affairs/releases/entangled_atoms.htm.

*M. Greiner, C.A. Regal, J.T. Stewart, and D.S. Jin. 2005. Probing Pair-Correlated Fermionic Atoms through Correlations in the Atom Shot Noise. Physical Review Letters, posted online March 21, 2005.

Media Contact:
Laura Ost, laura.ost@nist.gov, (301) 975-4034

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Billions in Cost Estimated for Firefighter Injuries

Firefighter

Firefighters face a high chance of injury or death whether on the scene of a fire, on the way to a fire or even during training—with an estimated 81,000 injuries and 100 deaths in 2002 alone. The National Institute of Standards and Technology (NIST) recently released a study* that estimates the cost in 2002 of addressing firefighter injuries and of efforts to prevent them to be $2.8 billion to $7.8 billion per year.

The study, conducted by the TriData Division of System Planning Corporation, Arlington, Va., for NIST, considered workers' compensation payments and other insured medical expenses, including long-term care; lost productivity and administrative costs of insurance. It also factored in labor costs of investigating injuries, along with the hours required for data collection, report writing and filing. Other costs related to preventing injuries and reducing their severity included expenditures for insurance coverage, safety training, physical fitness programs and protective gear and equipment.

The range between the $2.8 billion to $7.8 billion reflects different cost estimation models—one with a narrow approach to possible related firefighter injury costs, the others with broader views of economic impacts. Fire departments can use the information to plan their fire prevention and firefighting strategies. NIST plans to use the study as an aid to determining what new research might lead to a reduction in injury costs and to enhanced fire safety.

The study stressed the importance of programs that minimize emergency calls, prevent accidental fires, and reduce the incidents of arson. It also calls for early detection of fires using smoke detectors as well as improved on scene command procedures to locate firefighters and understand threats to them. The study praises firefighter bravery as “legendary and real,” but calls for new ways to instill safety awareness in firefighters. It also says that training injuries can be minimized by developing better virtual reality simulations for use in training firefighters.

Other suggested ways to prevent injury and to cut cost include: robots for reconnaissance and firefighting; early (remote) sensing of firefighter injuries/illnesses; computer modeling of deployment scenarios; early detection of building collapse; and emphasis on heightened firefighter health and fitness.

TriData Division, System Planning Corporation,The Economic Consequences of Firefighter Injuries and Their Prevention. Final Report, NIST GCR 05-874, March 2005

Media Contact:
John Blair, john.blair@nist.gov, (301) 975-4261

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Where’s Waldo’s DNA? New NIST SRM Joins Search

NIST principal investigator Barbara Levin (left) observes while NIST research chemist Diane Hancock pipettes a sample in preparation for an analysis of low-frequency mitochrondrial DNA mutations.

NIST principal investigator Barbara Levin (left) observes while NIST research chemist Diane Hancock pipettes a sample in preparation for an analysis of low-frequency mitochrondrial DNA mutations.

Photo by Barry Gardner
Click here to download a higher resolution version of this image.

A new reference standard from the National Institute of Standards and Technology (NIST) may help genetics labs develop improved methods of searching for a mutant needle in a DNA haystack.

A single DNA molecule carrying part of a person’s genetic code is a chain of basic chemical units called nucleotides. The number of nucleotides can range from about 16,500 in mitochondrial DNA (mtDNA) to several million in nuclear DNA. A key mutation in a DNA strand may involve only a single nucleotide and yet cause serious health effects.

Accurate analysis of mitochondrial DNA (mtDNA), either for forensic identification or for studying genetic-based diseases, often hinges on the ability to detect such mutations that occur only infrequently, even in the same individual. Unlike the cell's nuclear DNA, a person's mtDNA is often heteroplasmic—a mix of a dominant DNA sequence with fewer mutated sequences that differ from the dominant version by one or more nucleotides. There are hundreds or thousands of mitochondria in cells, and the exact percentage of the minority mtDNA in the mix can vary dramatically in an individual from tissue to tissue and even from cell to cell. In general, it can be very difficult to identify variants that make up less than 20 percent of the sample unless you already know they are there.

Researchers face a similar problem of detecting low-frequency variants when analyzing pooled samples of nuclear DNA from a population of individuals in the hope of identifying specific mutations responsible for genetic diseases.

To help the research community develop and test more sensitive techniques for detecting low-frequency mutations in heteroplasmic DNA, NIST researchers have developed a new Standard Reference Material, SRM 2394, “Heteroplasmic Mitochondrial DNA Mutation Detection Standard.” The new material is a set of mixtures, at 10 different certified concentrations, of two DNA fragments that differ from each other at only one position.

Media Contact:
Michael Baum, michael.baum@nist.gov, (301) 975-2763

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Quick Links

HIV/AIDS Structure Database is a Hit with Researchers

In the few short months since it was announced last summer (www.nist.gov/public_affairs/techbeat/tb2004_0715.htm#aids) the NIST HIV Structural Reference Database (HIVSDB) has logged about 2 million hits, making it one of the Institute’s most popular data services that doesn’t give the time. An information resource for the HIV research community, the HIVSDB collects, annotates, archives and distributes structural data for proteins involved in making HIV, the virus that causes AIDS, as well as molecules that inhibit the virus. The database is useful in developing new AIDS inhibitors by facilitating the online comparison of the existing hundreds of AIDS inhibitors on the basis of their ability to attack specific locations in the active site of the AIDS enzyme (HIV protease). The database is particularly valuable because it includes not only data from the widely used RCSB Protein Data Bank, but also previously unpublished data from industrial and other laboratories. The web interface also provides novel tools using a new method called Chem-BLAST to interactively compare inhibitors and study their interaction with the AIDS enzyme.

The NIST HIVSDB was developed in collaboration with the National Cancer Institute. The database was expanded recently to include two-dimensional structural data for 500 potent HIV protease inhibitor compounds supplied by the National Institute of Allergy and Infectious Diseases (NIAID). The entry point to the HIV Structural Data Base is at http://xpdb.nist.gov/hivsdb/hivsdb.html.

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New Facility Recognized in Lab Design Competition

The National Institute of Standards and Technology (NIST) and HDR Inc. will accept an award on March 29 for "high honors" in R&D Magazine’s 2005 Lab of the Year competition for the Advanced Measurement Laboratory, a new facility completed last year on NIST's Gaithersburg, Md., campus. HDR provided architecture and engineering services on the project.

The $235 million facility, regarded as the most technologically advanced research facility of its kind in the world, was judged by a jury of representatives from the architectural, scientific and laboratory equipment communities, as well as R&D Magazine editors. Specific criteria the judges considered included siting, planning, traffic flow, aesthetics, working conditions, lab design, opportunities for collaboration and idea exchange, energy efficiency, cost to build and cost to operate.

The AML is an essential part of NIST’s mission of advancing U.S. technological competitiveness. The new facility allows NIST to provide the sophisticated measurements and standards needed by U.S. industry and the scientific community for key 21st-century technologies such as nanotechnology, semiconductors, biotechnology, advanced materials, quantum computing and advanced manufacturing. It provides NIST researchers with simultaneous tight control of temperature, humidity, acoustics and vibration, as well as excellent air cleanliness and electrical power quality. The facility was dedicated on June 21, 2004.

For further information on the AML, see
www.nist.gov/public_affairs/releases/aml_dedication.htm.

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Fire Retardant Foam Consortium to Meet

Polyurethane foam is everywhere—from building insulation, to upholstered furniture, carpet padding to automotive and bedding products. The cellular plastic products, however, are under increased scrutiny for their flammability. At the same time, environmental concerns have caused manufacturers to stop using some of the more effective brominated flame retardants in the product.

To help industry respond, the National Institute of Standards and Technology (NIST) will host a meeting on April 20 at its Gaithersburg campus to discuss establishing a cooperative research consortium to develop information useful for the preparation of fire-safe foams that are environmentally safe and cost-effective. The industry-led consortium would create a database on foam flammability, develop generic measurement tools, and ultimately make recommendations for foam flammability testing methods and candidates for fire safe foams.

Manufacturers, additive suppliers, fire safety and environmental representatives are invited to participate in the meeting and consortium. Those interested in attending the free organizing meeting should contact Jeffery Gilman at (301) 975-6573, or jeffrey.gilman@nist.gov. The proposed consortium Web site is www.bfrl.nist.gov/866/foam/.


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How Long Should Digital Storage Media Last?

Knowing that CDs and DVDs will last for a certain number of years is critical to many government agencies, as well as to hospitals, banks and other organizations that store massive amounts of vital data on optical disks. But, how long is long enough?

To help the National Institute of Standards and Technology (NIST) develop a standard test to estimate the longevity of recordable optical media, the DVD Association (DVDA) and the Government Information Preservation Working Group (GIPWoG) are asking federal agencies and other organizations to answer a very brief survey concerning the longevity of optical media. The deadline for responding is May 31, 2005.

The test being developed by NIST will not measure actual longevity but will determine the archival quality of the media and whether it will last at least a minimum number of years. The NIST researchers recently tested how well recordable optical disks made with different manufacturing processes held up when exposed to high temperatures, humidity and light levels. They found that some disks can be expected to store data reliably for several tens of years. (A Web site on the NIST/Library of Congress Optical Media Longevity Study can be found at www.itl.nist.gov/iad/894.05/loc.)

This item was edited on Sept. 20, 2007, to correct for a change in the URL of the referenced Web site.

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NIST, Utah State Collaborate on Sensor Technology

An agreement signed March 14 between the National Institute of Standards and Technology (NIST) and Utah State University (USU) creates a formal partnership for collaboration in the development and calibration of optical sensors for defense, homeland security, weather prediction and climate research.

The signing ceremony was hosted by Utah Senator Bob Bennett with Under Secretary of Commerce for Technology Phillip Bond, NIST Acting Director Hratch Semerjian, USU President Stan Albrecht, Utah Senator Orrin Hatch, staff from Utah Rep. Rob Bishop’s office, and other NIST and USU representatives in attendance.

“NIST is signing this memorandum of understanding today because we believe that, by working together, exchanging people, and sharing resources, our institutions can spur greater progress in innovation, research and education,” said Bond.

NIST and Utah State have an extensive history of collaboration in measurements and standards for optical instruments, with an emphasis on space-based applications. The Memorandum of Understanding (MOU) will enhance that partnership. The two organizations will address areas of critical technical importance for improving national security and calibrating instruments used in assessing the extent and consequences of climate change, a necessary prerequisite for developing effective environmental policies. Other potential areas of collaboration include biotechnology, nanotechnology, and computational chemistry.

For additional information, see www.nist.gov/public_affairs/releases/nist_usu_partner.htm.

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Editor: Gail Porter

Date created:3/22/05
Date updated:9/20/2007

Contact: inquiries@nist.gov