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altretamine A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity. Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms: | | Hemel Hexaloids | | | US brand names: | | Hexalen hexamethylmelamine | | | Foreign brand names: | | Hexastat Hexinawas | | | Abbreviations: | | HMM HXM | | | Code names: | | ENT-50852 RB-1515 WR-95704 | | | Chemical structure names: | | - 2,4,6-tris(dimethylamino)-s-triazine
- N,N,N',N',N",N"-hexamethyl-1,3,5-triazine-2,4,6-triamine
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