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monoclonal antibody CHIR-12.12 A monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Monoclonal antibody CHIR-12.12 binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20081005100443im_/http://www.nci.nih.gov/images/spacer.gif) | MOAB CHIR-12.12 | | ![](https://webarchive.library.unt.edu/eot2008/20081005100443im_/http://www.nci.nih.gov/images/spacer.gif) |
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