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niacinamide The active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081005083519im_/http://www.nci.nih.gov/images/spacer.gif) | 3-Pyridinecarboxamide nicotinamide Nicotinamidum Nicotinic Acid Amide Nicotylamide Pellagra-Preventing Factor Vitamin PP | | ![](https://webarchive.library.unt.edu/eot2008/20081005083519im_/http://www.nci.nih.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/eot2008/20081005083519im_/http://www.nci.nih.gov/images/spacer.gif) | Nicamid Nicosedine | | ![](https://webarchive.library.unt.edu/eot2008/20081005083519im_/http://www.nci.nih.gov/images/spacer.gif) |
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