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AML mRNA plus lysate loaded autologous dendritic cell vaccine
A cancer vaccine consisting of autologous dendritic cells loaded with separate preparations of acute myelogenous leukemia (AML) cell lysate and AML-specific messenger RNA (mRNA) with potential immunostimulatory and antineoplastic activities. Upon administration, AML mRNA plus lysate loaded autologous dendritic cell vaccine may elicit a potent cytotoxic T-cell (CTL) response against AML cells, resulting in tumor cell death.
Autologous dendritic cells doubly-loaded with AML cell lysate and AML-specific mRNA may elicit superior primary, recall, and effector lytic immune responses compared to autologous dendritic cells loaded with tumor lysate or tumor mRNA alone. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonym: | | acute myelogenous leukemia mRNA plus lysate loaded autologous dendritic cell vaccine | | |
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