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ISIS 3521 A synthetic phosphorothioate oligodeoxynucleotide. As an antisense molecule, ISIS 3521 hybridizes to the 3-untranslated region of the human protein kinase C (PKC-alpha) mRNA, thereby inhibiting PKC-alpha expression and growth of PKC-alpha-dependent tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081005073121im_/http://www.nci.nih.gov/images/spacer.gif) | DNA, d(P-thio)(GTTCTCGCTGGTGAGTTTCA) Protein Kinase C-Alpha Antisense | | ![](https://webarchive.library.unt.edu/eot2008/20081005073121im_/http://www.nci.nih.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20081005073121im_/http://www.nci.nih.gov/images/spacer.gif) | Affinitac Affinitak | | ![](https://webarchive.library.unt.edu/eot2008/20081005073121im_/http://www.nci.nih.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20081005073121im_/http://www.nci.nih.gov/images/spacer.gif) | CGP 64128A LY900003 | | ![](https://webarchive.library.unt.edu/eot2008/20081005073121im_/http://www.nci.nih.gov/images/spacer.gif) |
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