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enzastaurin hydrochloride The hydrochloride salt of enzastaurin, a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081005071319im_/http://www.nci.nih.gov/images/spacer.gif) | LY-317615 | | ![](https://webarchive.library.unt.edu/eot2008/20081005071319im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081005071319im_/http://www.nci.nih.gov/images/spacer.gif) | 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione Dihydrochloride | | ![](https://webarchive.library.unt.edu/eot2008/20081005071319im_/http://www.nci.nih.gov/images/spacer.gif) |
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