![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif) |
|
![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif)
ranpirnase A natural homologue of ribonuclease A isolated from the eggs of the frog Rana pipiens. Ranpirnase primarily degrades cellular transfer RNA with a substrate specificity for uridine-guanidine base-pair sequences, resulting in inhibition of protein synthesis and cytotoxicity. This agent also activates caspase-9 in mitochondria, resulting in tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif)
Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif) | P-30 P-30 protein | | ![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif) | Onconase | | ![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif) |
![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/gray_spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif)
|
![](https://webarchive.library.unt.edu/eot2008/20081005062219im_/http://www.nci.nih.gov/images/spacer.gif) |