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thioredoxin-1 inhibitor PX-12 An orally bioavailable small molecule with potential antineoplastic activity. Thioredoxin-1 inhibitor PX-12 irreversibly binds to thioredoxin-1 (Trx-1) and inhibits its activity, which may result in growth inhibition and the induction of apoptosis. Overexpressed in many cancer cell types, the low molecular weight redox protein Trx-1 regulates transcription factor activity and inhibits apoptosis, promoting cell growth and survival; it also interacts with growth factors extracellularly to stimulate cell growth. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/eot2008/20081005055524im_/http://www.nci.nih.gov/images/spacer.gif) | PX-12 | | ![](https://webarchive.library.unt.edu/eot2008/20081005055524im_/http://www.nci.nih.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20081005055524im_/http://www.nci.nih.gov/images/spacer.gif) | 1-methylpropyl 2-imidazolyl disulfide | | ![](https://webarchive.library.unt.edu/eot2008/20081005055524im_/http://www.nci.nih.gov/images/spacer.gif) |
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