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tirapazamine A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20081005061400im_/http://www.nci.nih.gov/images/spacer.gif) | Tirazone | | ![](https://webarchive.library.unt.edu/eot2008/20081005061400im_/http://www.nci.nih.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20081005061400im_/http://www.nci.nih.gov/images/spacer.gif) | SR 4233 WIN 59075 | | ![](https://webarchive.library.unt.edu/eot2008/20081005061400im_/http://www.nci.nih.gov/images/spacer.gif) |
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