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NCI International Portfolio:

Addressing the Global Challenge of Cancer




Director's Message






Research Areas and Partnering Nations






Introduction






Understanding the Causes and Mechanisms of Cancer






Accelerating Progress in Cancer Prevention






Improving Early Detection and Diagnosis






Developing Effective and Efficient Treatments






Understanding the Factors that Influence Outcomes






Improving the Quality of Cancer Care






Improving Quality of Life






Improving Cancer Communications






Scientist Exchanges and Training Programs






Building the Capacity and Infrastructure



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Introduction

Addressing the Global Challenge of Cancer
The global burden of cancer is large and growing larger. Each year, more than 11 million people are diagnosed with cancer worldwide. By the year 2020, this number is expected to increase to 16 million. In addition, cancer causes more than 8 million deaths each year -- or approximately 13 percent of all deaths worldwide.

In many developed countries, including the United States, cancer accounts for more than 20 percent of all deaths. In less developed countries, overall cancer rates are generally lower and cancer accounts for a lower percentage of deaths. However, it is within developing countries that cancer is projected to increase most rapidly over the next few decades. Unless current trends change, cancer in developing countries is expected to represent 70 percent of the global cancer burden by the year 2030, a statistic driven by demographic shifts toward more elderly populations and the movement toward more Western lifestyles, most notably increased per capita tobacco consumption and higher fat-lower fiber diets.

In the National Cancer Act of 1971, the National Cancer Institute (NCI) was charged to: "Collect, analyze, and disseminate all data useful in the prevention, diagnosis, and treatment of cancer…[and to] disseminate insofar as feasible the results of cancer research undertaken in any country for the use of any person involved in cancer research in any country." In addition, the Institute was directed to: "Support research in the cancer field outside the United States by highly qualified foreign nationals…; support collaborative research involving American and foreign participants; and support the training of American scientists abroad and foreign scientists in the United States."

Clearly, it was the intent of the U.S. Congress that NCI should not only address the challenge of cancer among American citizens but also among the citizens of all nations. This challenge is daunting indeed, but it is one from which we cannot shrink.

Expanded Research Opportunities
A global perspective offers a myriad of research opportunities that a U.S.-only research focus would not afford. For example, international studies enable us to investigate "rare" cancers -- such as certain inherited, familial types of kidney cancer, melanoma, and other cancers -- by providing access to much larger populations of patients than can be found within the confines of our national borders. A global perspective also opens to us the diversity of environments occupied by humans, providing unique opportunities to explore relationships between genes and specific environmental exposures, including infectious agents that may be associated with cancer.

Furthermore, international programs give us access to resources found only in other countries. These resources allow for consistency in diagnosis and tumor classification.

Shared Knowledge and Capacity Building
NCI also recognizes the importance of investing in developing countries, especially with respect to improving research and health care infrastructure. No nation exists in a vacuum and cancer does not recognize international borders. NCI is committed to sharing our expertise to foster cancer research and build research and health care infrastructure around the world. Just as American researchers benefit from a broader perspective by engaging in research outside U.S. borders, international researchers make significant contributions to NCI's overall mission while acquiring knowledge, skills, and abilities to enhance the research environment in their home countries.

The mission to train both American and foreign scientists to battle cancer is one that NCI takes seriously. When we cooperate internationally to address a shared health burden, knowledge is expanded, solutions are discovered more efficiently, and the health of all people is improved.

NCI's Office of International Affairs
Monitoring NCI's international activities, many of which are managed within the Institute's intramural and extramural divisions, is the responsibility of the Office of International Affairs (OIA). OIA also directs a range of activities that are intended to catalyze research advances through individual and group training and through fostering interactions between cancer researchers in the United States and abroad. These latter activities include initiating, developing, and implementing bilateral and multilateral agreements to share information and expertise with other nations and groups of nations. One excellent example of this type of OIA activity is the Middle East Cancer Consortium (MECC), which is described in Building the Capacity and Infrastructure for Cancer Research and Care.

OIA also coordinates NCI's involvement in the global clinical trials enterprise. This key role for OIA is demonstrated by the work of NCI's Liaison Office in Brussels, Belgium (see The NCI Liaison Office in Europe).

NCI's International Portfolio
This report provides an overview and brief descriptions of NCI's international cancer control and research programs, as well as the Institute's efforts to share scientific knowledge, build and support cancer research infrastructure in other nations, and improve the delivery of cancer information and care to people around the globe. You will find compelling reports that demonstrate NCI's efforts towards addressing the global challenge of cancer. However, keep in mind that the efforts and activities presented here are just a sample of the work being done by NCI scientists, our grantees, and our international partners.

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