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Research
Complete list of publications
Wang IE, J Shan, R Choi, , S Oh, CK Kepler, FH Chen and HH Lu: Role of Osteoblast-Fibroblast Interactions in the Regeneration of the Ligament-to-Bone Interface. In press, J Orthop Res, 2007, Aug 3, 2007 Epub.
Lu, X, C. Miller, F.H. Chen, X.E Guo, and V.C. Mow: The generalized triphasic correspondence principle for simultaneous determination of the mechanical properties and proteoglycan content of articular cartilage by Indentation. J Biomech. 40:2434-41, 2007
Kurth,T, E Hedbom, N Shintani, FH Chen, M Haspl, S Martinovic and EB Hunziker: Chondrogenic potential of human synovial mesenchymal stem cells in alginate. OA & Cartilage, 15:1178-89, 2007.
Chen, F.H., M.E. Herndon, N. Patel, J.T. Hecht, R.S. Tuan, and J Lawler: Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem, 282:24591-98, 2007
Basalo I.M., N.O. Chahine, F.H. Chen, C.T. Hung, and G.A. Ateshian: Chondroitin sulfate reduces the friction coefficient of articular cartilage. J Biomech. 40:1847-54, 2007
Wang, I.E., S. Mitroo, F.H. Chen, H.H. Lu and S.B. Doty. Age-Dependent Changes in Matrix Composition and Organization at the Ligament-to-Bone Insertion. J Orthop Res, 24:1745-55, 2006
Ishii, Y., A.O. Thomas, G.A. Ateshian, X.E. Guo, C.T. Hung, and F.H. Chen: Localization and distribution of cartilage oligomeric matrix protein in spine. Spine. 31:1539-46, 2006
Chen, F.H., K.T. Rousche, and R.S. Tuan: Tchnology Insight: adult stem cells in cartilage regeneration and tissue engineering. Nature Clin Pract Rheum.2:373-82, 2006.
Basalo I.M., F.H. Chen, C.T. Hung, and G.A. Ateshian: Frictional response of bovine articular cartilage under creep loading following proteoglycan digestion with chondroitinase ABC. J Biomech Eng 128:128-31, 2006
Chen, F.H., A. O. Thomas, M. B. Goldring and J Lawler: Cartilage oligomeric matrix protein supports chondrocyte attachment though interaction with integrin. J Biol Chem. 280:32655-61, 2005
Chahine, N.O., FH Chen, CT Hung, and GA Ateshian: Direct measurement of osmotic pressure of glycosaminoglycan solution by membrane osmometry at room temperature. Biophys J 89:1543-50, 2005
Basalo IM, D Raj, R Krishnan, FH Chen, CT Hung and GA Ateshian: Effects of enzymatic degradation on the frictional response of articular cartilage in stress relaxation. J Biomech. 38:1343-9, 2005
Lu X., D.D. Sun, X.E. Guo, F.H. Chen, W.M. Lai, and V.C. Mow: Determination of Proteoglycan Content using the Biphasic Indentation Method. Ann Biomed Eng. 32:370-379, 2004
Basalo I.M., R.L. Mauck, T.A. Kelly, S.B. Nicoll, F.H. Chen, C.T. Hung, and G.A. Ateshian: Cartilage interstitial fluid support in unconfined compression following enzymatic digestion. J Biomechan Eng, 126:779-86, 2004.
Riessen, R., M. Fenchel, H. Chen, D.I. Axel, K.R. Karsch, and J. Lawler. Cartilage oligomeric matrix protein (thrombospondin-5) is expressed by human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 21:47-54, 2001.
Chen, H., M.E. Herndon, and J. Lawler. The cell biology of thrombospondin 1. Matrix Biol. 19: 597-614, 2000
Chen, H., M. Deere, J.T. Hecht, and J. lawler. Cartilage oligomeric matrix protein is a calcium-binding protein, and a mutation in its type 3 repeats causes conformational changes. J. Biol Chem. 275: 26538-26544, 2000.
Danik, M., A.M. Chinn, B. Lafeuillade, M. Keramidas, S. Aguesse-Germon, A.H. Penhoat, H. Chen, D.F Mosher, E.M. Chambaz, and J.J. Feige. Bovine thrombospondin-2: complete cDNA sequence and immunolocalization in the external zones of the adrenal cortex. Endocrinology. 140: 2771-2780, 1999.
Hecht, J. T., M. Deere, E. Putnam, W. Cole, B.M Vertel, H. Chen, and J. Lawler. Characterization of cartilage oligomeric matrix protein (COMP) in human normal and pseudoachondroplasia musculoskeletal tissues. Matrix Biol. 17: 269-278, 1998.
Panetti, T. S., H. Chen, T. Misenheimer, S.B. Getzler, and D.F. Mosher. Endothelial cell mitogenesis induced by LPA: inhibition by thrombospondin-1 and -2. J. Lab. Clin. Med. 129: 208-216, 1997.
Chen, H., J. Sottile, D.K. Strickland, and D.F Mosher. Binding and degradation of thrombospondin-1 mediated through heparin sulfate proteoglycans and low-density-lipoprotein receptor-related protein: localization of the functional activity to the trimetric N-terminal heparin-binding region of thrombospondin-1. Biochem. J. 318: 959–963, 1996.
Chen, H., D.K. Strickland, and D.F. Mosher. Metabolism of thrombospondin 2: binding and degradation by 3T3 cells and glycosaminoglycan-variant cells. J. Biol. Chem. 271:15993-15999, 1996.
Chen, H., D. Aeschlimann, J. Nowlen, and D.F. Mosher. Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3. FEBS Lett. 38: 36-41, 1996.
Chen, H., and D.F. Mosher. Formation of sodium dodecyl sulfate-stable fibronectin multimers: failure to detect products of thiol-disulfide exchange in cyanogen bromide or limited acid digests of stabilized matrix fibronectin. J. Biol. Chem. 271: 9084-9089, 1996.
Volpert, O.V., S.S. Tolsma, S. Pellerin, J. Feige, H. Chen, D.F. Mosher, and N. Bouck. Inhibition of angiogenesis by thrombospondin-2. Biochem. Biophys. Res. Commun. 217:326-332, 1995.
Schlultz-Cherry, S., H. Chen, D.F. Mosher, T.M. Misenheimer, H.C. Krutzsch, D.D. Roberts, and J.E. Murphy-Ullrich. Regulation of TGF-ß activation by discrete sequences of thrombospondin 1. J. Biol. Chem. 270: 7304-7310, 1995.
Chen, H., J. Sottile, K.M. O'Rourke, V.M. Dixit, and D.F. Mosher. Properties of recombinant mouse thrombospondin 2 expressed in spodoptera cells. J. Biol. Chem. 269:32226-32232, 1994.