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Trichloroethylene(TCE) Subregistry Baseline Technical Report 1994

DISCLAIMER

The use of company or product names is for identification only and does not constitute endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services.

CONTENTS
• LIST OF TABLES
• LIST OF FIGURES
• APPENDICES
• EXECUTIVE SUMMARY
• SECTION 1--INTRODUCTION
• SECTION 2--THE SELECTION OF TCE AS A PRIMARY CONTAMINANT
  • Environmental Information
    
  • Human Data
    
  • Animal Data
    
• SECTION 3--TCE SITES: SELECTION AND DESCRIPTION
  
  • Decription of TCE Subregistry Sites
    
    • Michigan
      
    • Indiana
      
    • Illinois
      
• SECTION 4--DESCRIPTIVE DATA: ENVIRONMENTAL AND REGISTRANT
  
  • On-Site Activities
    
  • Coverage of Designated Household Addresses
    
  • Population Summary
    
  • Registrant Descriptive Data
    
• SECTION 5--COMPARISON OF TCE SUBREGISTRY DATA AND NATIONAL DATA
  
  • Rationale for the Comparison of the TCE Subregistry
    
  • Data with National Data
    
  • National Comparison Populations
    
  • Selection of NHIS
    
  • Selection of NHSDA
    
  • Methods of Descriptive Variable Comparisons
    
  • Demographic Characteristics
    
  • Methods of Comparing Health Outcomes
    
  • Question Comparability
    
  • Statistical Analysis of Health Data
    
  • Statistical Analysis of Cancer Data
    
  • Results of Descriptive Comparisons
    
  • Demographics
    
  • Results of Health Outcome Comparisons
    
  • Controlling for Age and Sex
    
  • Controlling for Age, Sex, and Education
    
  • Comparison with SEER Data
    
• SECTION 6--MORTALITY DATA ANALYSES
  
  • Statistical Analyses
    
  • Variables
    
  • Statistical Methods
    
  • Results
    
• SECTION 7--INTRASUBREGISTRY FILE EXPOSURE GROUP COMPARISONS
  
  • Comparison of Health Outcomes Across Exposure Groups
    
  • Creation of Exposure Subgroups
    
  • Variables Used in Analyses
    
  • Statistical Methods
    
  • Results of Exposure Subgroup Comparisons
    
• SECTION 8--DISCUSSION
  
  • Environmental Data
    
  • Health Outcomes
    
  • Skin Rashes, Eczema, or Other Skin Allergies
    
  • Speech Impairment
    
  • Hearing Impairment
    
  • Diabetes
    
  • Effects of Stroke
    
  • Urinary Tract Disorders, Including Prostate Trouble
    
  • Kidney Disease
    
  • Anemia or Other Blood Disorders
    
  • Cancer
    
  • Summary
    
• SECTION 9--CONCLUSIONS AND RECOMMENDATIONS
  
  • Conclusions
    
  • Recommendations
    

LIST OF TABLES

• Table 3-1.--Summary of environmental data by site
  
• Table 3-2.--Total number of positive water samples per site address
  
• Table 3-3.--Verona Well Field and Dowagiac, Michigan, residential wellsampling
  
• Table 3-4.--McGraw-Edison Corporation, Michigan, residential well sampling
  
• Table 3-5.--Superior Street, Elkhart, Indiana, residential well sampling
  
• Table 3-6.--Central Area, Elkhart, Indiana, residential well sampling
  
• Table 3-7.--Gemeinhardt Piccolo Company, Elkhart, Indiana, residential well sampling
  
• Table 3-8.--Conrail Rail Yard, Elkhart, Indiana, residential well sampling
  
• Table 3-9.--Acme Solvents Reclamation, Inc., Illinois, residential well sampling
  
• Table 3-10.--Beloit Corporation, Illinois, residential well sampling
  
• Table 3-11.--Byron Johnson Salvage Yard, Illinois, residential well sampling
  
• Table 3-12.--Frinks Industrial Waste, Illinois, residential well sampling
  
• Table 3-13.--Southeast Rockford Groundwater Contamination, Illinois, residential well sampling
  
• Table 3-14.--Warner Electric Brake and Clutch Company, Roscoe, Illinois,residential well sampling
  
• Table 4-1.--Living registrants with complete occupancy data
  
• Table 4-2.--Descriptive coverage by site
  
• Table 4-3.--Number of participants in the TCE baseline
  
• Table 4-4.--Participation rate by site
  
• Table 4-5.--Descriptive data for living registrants (all sites)
  
• Table 4-6.--Tobacco use data for TCE registrants 18 years of age or older (all sites)
  
• Table 4-7.--Descriptive data for deceased registrants (all sites)
  
• Table 5-1.--Comparison of time frames for health condition questions
  
• Table 5-2.--Comparison of TCE and NHIS health questions
  
• Table 5-3.--Comparison of NHIS-TCE Subregistry population age groups 53
  
• Table 5-4.--Age-specific distribution of white males 54
  
• Table 5-5.--Mean years of education of NHIS and TCE Subregistry participants by age and sex
  
• Table 5-6.--Reported rates of cigarette smoking
  
• Table 5-7.--Smoking rates by educational attainment
  
• Table 5-8.--Comparison of TCE and NHIS participants reporting health condition
  
• Table 5-9.--Summary of TCE Subregistry response rates for cancer
  
• Table 5-10.--Summary of Poisson regression modeling
  
• Table 5-11.--Summary of observed and expected health outcomes using multivariate models
  
• Table 5-12.--Summary of results
  
• Table 5-13.--Summary of Poisson regression modeling, including adjustments for education
  
• Table 5-14.--Comparison of TCE Subregistry and SEER cancer rates (males)
  
• Table 5-15.--Comparison of TCE Subregistry and SEER cancer rates (females)
  
• Table 5-16.--Comparison of TCE Subregistry and SEER cancer rates (all registrants)
  
• Table 6-1.--Comparison of living and deceased by location and sex
  
• Table 6-2.--Comparison of location for deceased and living
  
• Table 6-3.--Summary of death certificate data
  
• Table 6-4.--Summary of standardized mortality ratios (SMRs)
  
• Table 6-5.--Significant results of life table analyses (analysis restricted to registrants 15 years of age or older at time of death)
  
• Table 7-1.--Summary of age, sex, educational attainment, and smoking history by site
  
• Table 7-2.--Summary of levels of other chemicals by TCE level
  
• Table 7-3.--Summary of other chemicals present
  
• Table 7-4.--Summary of length of exposure and cumulative exposure by site
  
• Table 7-5.--Summary of descriptive variables by exposure groups
  
• Table 7-6.--Logistic regression analysis (categorical maximum TCE exposure, adjusted for age and sex)
  
• Table 7-7.--Logistic regression analysis (categorical cumulative TCE exposure, adjusted for age and sex)
  
• Table 7-8.--Logistic regression analysis (cumulative chemical exposure, adjusted for age and sex)
  
• Table 7-9.--Logistic regression analysis (categorical TCE exposure, adjusted for age, sex, smoking, occupational exposure, and education)
  
• Table 7-10.--Logistic regression analysis (categorical cumulative TCE exposure, adjusted for age, sex, smoking, occupational exposure, and education)
  
• Table 7-11.--Logistic regression analysis (categorical cumulative chemical exposure adjusted for age, sex, smoking, occupational exposure, and education)
  
• Table 7-12.--Logistic regression analysis (maximum TCE exposure adjusted for age, sex, smoking, occupational exposure, and education)
  
• Table 7-13.--Logistic regression analysis (cumulative chemical exposure adjusted for age, sex, smoking, occupational exposure, location, and education)
  
• Table 7-14.--Logistic regression analysis (length of exposure categories, adjusted for age and sex)
  
• Table 7-15.--Logistic regression analysis (length of exposure categories adjusted for age, sex, smoking, occupational exposure, and education)
  
• Table 7-16.--Summary of exposure category analyses
  
• Table 8-1.--Summary of environmental groups analyses
  
• Table 8-2.Summary results of NHIS comparison
  
• Table 8-3.--Summary of mortality analyses 1985-1989 (analysis restricted to registrants 15 years of age and older at time of death)
  
• Table 8-4.--Number of cases of diabetes per 1,000 persons, by geographic region and place of residence: United States, 1989-1990

LIST OF FIGURES

• Figure 2-1.--Number and types of TCE sites in 1988
  
• Figure 2-2.--Availability of information on health effects of TCE (human data)
  
• Figure 2-3.--Availability of information on health effects of TCE (animal data)
  
• Figure 4-1.--Geographic distribution of registrants (living and deceased)
  
• Figure 7-1.--Summary of site exposure periods
  

LIST OF APPENDIX

• Appendix A
  

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