Guidance Manual
for the
Assessment of Joint Toxic Action of Chemical Mixtures
May 2004
Complete Manual - This is the whole manual in one large PDF file. (file
size 577k)
The table of contents and list of individual PDF files are given below.
Preface - (file size 45k)
- Summary
- Contributors
- Peer review
- Contents
- List of figures
- List of tables
- List of acronyms, abbreviations, and symbols
- Executive Summary
Chapter 1 - Overview (file size 28k)
Chapter 2 - Options and Issues for the Assessment of Joint Toxic
Action of Chemical Mixtures (file size 125k)
- 2.1 Mixture of Concern
- 2.2 Component Mixtures
- Relevance of the Interactions Data and Approach to Public Health
Chapter 3 - Methods Used or Proposed by Other Agencies (file size
26k)
Chapter 4 - ATSDR Approach (file size 137k)
Chapter 5 - References (file size 34k)
Appendices - (file size 259k)
- A. Background Information on the assessment of additivity and interactions
- B. Weight-of-Evidence methods
- C. The integral search system for ranking hazards of mixtures of carcinogens
Reference
Agency for Toxic Substances and Disease Registry (ATSDR). 2004. Guidance manual for the assessment of joint toxic actions of chemical mixtures. Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service.
Disclaimer
All ATSDR Interaction Profile PDF files are electronic conversions from paper copy or other electronic ASCII text files. This conversion may have resulted in character translation or format errors. Users are referred to the original paper copy of the interaction profile for the official text, figures, and tables. Original paper copies can be obtained via the directions on the Interaction Profiles Home Page, which also contains other important information about the profiles.
Where can I get more information?
ATSDR can tell you where to find occupational and environmental health clinics. Their specialists can recognize, evaluate, and treat illnesses resulting from exposure to hazardous substances. You can also contact your community or state health or environmental quality department if you have any more questions or concerns.
For more information, contact:Agency for Toxic Substances and Disease Registry
Division of Toxicology and Environmental Medicine
1600 Clifton Road NE, Mailstop F-32
Atlanta, GA 30333
Phone: 1-800-CDC-INFO • 888-232-6348 (TTY)
Email: cdcinfo@cdc.gov
